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Prior to administration, BOTOX® must be reconstituted with sterile, preservative-free saline. The volume of diluent added determines the Unit dosage of BOTOX® per mL. In patients with cerebral palsy, concentrations of 100 U/mL are commonly employed. Dilution and reconstitution to produce 50 and 100 U/mL concentrations are illustrated on the slide.
The faculty recommends that the BOTOX® dose be referred to by Units rather than volume (eg, 100 U, not 1.0 mL).