Based on study results of animals with upper motoneuron lesions, Taub et al focused on the use of constraint-induced training. Notably, patients eligible for this approach have some use of the extremity before intervention. The efficacy of this approach has been demonstrated by Crocker et al in a child with spastic cerebral palsy.

The non-involved hand was placed in a splint to force the child to use the affected extremity. The patient demonstrated increased use of the spastic extremity in free play, eating, and with standardized tests of fine motor skill.

Crocker MD, MacKay-Lyons M, McDonnell E. Forced use of the upper extremity in cerebral palsy: a single-case design. Am J Occup Ther 1997;51: 824-33.
Taub E, Miller NE, Novack TA, et al. Technique to improve chronic motor deficit after stroke. Arch Phys Med Rehabil 1993;74:347-53.