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Benzodiazepines have a wide margin of safety. However, they can produce CNS depression with a resultant sedation, respiratory depression and inhibition of cardiovascular function. Paradoxical irritability can occur.
True physiological withdrawal can develop. A withdrawal syndrome has been described and consists of the following: agitation, anxiety, restlessness, tremor, muscle fasciculation and twitching, insomnia, nightmares, seizures, hyperpyrexia and hallucinations.
Paradoxical sleep disorders can also occur. Patients may also experience increased oral secretions. When weaning from this medication, taper over 3 to 6 months.