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Potential side effects include CNS depression and weakness. The former may manifest as sedation, drowsiness, and fatigue. In patients with epilepsy, baclofen may decrease their seizure threshold. Baclofen-induced weakness may produce a deterioration in the ability of some patients to walk. In addition, orthostatic hypotension may occur.
Patients may also experience increased oral secretions. Elevations in transaminases have been reported and liver function tests should be monitored. The drug should never be stopped suddenly; sudden withdrawal may precipitate a syndrome that includes hallucinations, psychosis and seizures.
Baclofen Package Insert, 2000.