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An evidence-based update to the 2004 guidelines for the treatment of infantile spasms has recently been published. Important new recommendations include use of low-dose adrenocorticotropic hormone (ACTH) over high-dose ACTH or vigabatrin. A paucity of data, however, leaves several key questions unanswered
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The Annual Bristol Paediatric Neurology Masterclass will be held on 18 & 19 April 2013
Topics include:
Syncope and anoxic seizures
Epilepsy in adolescence
Chanellopathies
Neurocutaneous disorders
Peripheral neuropathies
Traumatic Brain Injury
Congenital infections of CNS
Management of “difficult” epilepsies
Movement disorders
Cerebellar disorders
Neurogenetics
Stroke
Autoimmune disorders of the CNS
Neurotransmitter disorders
Faculty includes:
John Livingston (Leeds)
Sameer Zuberi (Glasgow)
Andrew Lux (Bristol)
Dana Craiu (Bucharest)
Rima Nabbout (Paris)
Richard Appleton (Liverpool)
Sergiusz Józwiak (Warsaw)
Alexander Paciorkowski (Rochester NY)
Anirban Majumdar (Bristol)
Alasdair Parker (Cambridge)
Eugen Boltshauser (Zurich)
Rob Forsyth (Newcastle)
Manju Kurian (London)
Angela Vincent (Oxford)
Finbar O’Callaghan (Bristol)
Mark Mackay (Melbourne)
Brigitte Vollmer (Southampton/Stockholm)
With Wine Reception and Conference Dinner on the s.s. Great Britain
Venue: University of Bristol, Chemistry Building, Cantock's Close, Bristol BS8 1TS
For any queries please contact us at This email address is being protected from spambots. You need JavaScript enabled to view it.or +44 (0) 117 342 0176 / 0160
Booking form 2013
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The Myotubular Trust announces A Fifth Call To Grant Application. The trust is looking to fund further projects that will help find a cure and/or a treatment for any of the three types of myotubular myopathy (congenital X-linked recessive; congenital autosomal recessive; autosomal dominant), focusing on research that would not generally be funded by public or industrial funding sources. The call is open to research bodies internationally.
To date, the trust have awarded six research grants / fellowships for the following projects:
- Gene therapy for x-linked myotubular myopathy and pathophysiology – Dr Anna Buj Bello, Genethon, Evry
- Membrane trafficking and T tubule structure and function in a canine model of centronuclear myopathies – Dr Richard Piercy, Royal Veterinary College, London
- Deciphering the molecular pathway involving centronuclear myopathy genes – Manuela D’Alessandro, IGBMC, Illkirch
- Gene therapy for autosomal dominant centronuclear myopathy by Transplicing – Dr Marc Bitoun, INSERM, Paris
- Next generation sequencing to tackle centronuclear myopathies – Dr Jocelyn Laporte, IGBMC, France
- Secondary pathogenic mechanisms in XLMTM and CNM – Dr Susan Treves, Basel University Hospital, Basel and Dr Heinz Jungbluth, King’s College London
In particular the trust encourages the application of new technologies to research into myotubular myopathy, which may involve collaboration between different medical disciplines and / or different research institutions. They are also willing to consider applications which involve joint funding with other organisations.
Please see the Myotubular trust Research Programme & Grants Information Page to read more and download an application form.
Source: The Myotubular Trust
The Myotubular Trust is not affiliated to The International Child Neurology Association (ICNA)
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A European team of scientists have built the first atlas of white-matter microstructure in the human brain. The project’s final results have the potential to change the face of neuroscience and medicine over the coming decade.
The work relied on groundbreaking MRI technology and was funded by the EU’s future and emerging technologies program with a grant of 2.4 million Euros. The participants of the project, called CONNECT, were drawn from leading research centers in countries across Europe including Israel, United Kingdom, Germany, France, Denmark, Switzerland and Italy.
The project investigators met on October 19, 2012 in Paris, after 3 years of research, to announce the conclusion of the project and present a report of their findings.
The new atlas combines three-dimensional images from the MRI scans of 100 brains of volunteers. To achieve this, CONNECT developed advanced MRI methods providing unprecedented detail and accuracy.
Professor Daniel Alexander, a CONNECT steering committee member from the UCL Department of Computer Science said: "The UCL team use the latest computer modelling algorithms and hardware to invent new imaging techniques. The techniques we devised were key to realising the new CONNECT brain atlas."The imaging techniques reveal new information about brain structure that help us understand how low-level cellular architecture relate to high-level thought processes."
Currently, biomedical research teams around the world studying brain science rely on a brain atlas produced by painstaking and destructive histological methods on the brains of a few individuals who donated their bodies to science.
The new atlas simulates the impossible process of painstakingly examining every mm2 of brain tissue (of which there are around 100 million per brain) with a microscope, while leaving the brain in tact.
The key novelty in the atlas is the mapping of microscopic features (such as average cell size and packing density) within the white matter, which contains the neuronal fibers that transmit information around the living brain. The results of the project, obtained through advanced image processing techniques, provide new depth and accuracy in our understanding of the human brain in health and disease.
The atlas describes the brain's microstructure in standardized space, which enables non-expert users, such as physicians or medical researchers, to exploit the wealth of knowledge it contains. The atlas contains a variety of new images that represent different microscopic tissue characteristics, such as the fiber diameter and fiber density across the brain, all estimated using MRI. These images will serve as the reference standard of future brain studies in both medicine and basic neuroscience.
The project will dramatically facilitate and promote future research into white matter structure and function. Historically in neuroscience, the vast majority of research effort has been invested in understanding and studying gray matter and neurons, while white matter has received relatively little attention.
This owes largely to the lack of effective research tools to study white matter, even though it comprises about half the volume of the brain. The new MRI methods that were developed in CONNECT allow researchers, for the first time, to visualize the micro-structure of the living brain over the whole brain.
This opens new realms in our understanding of our most complex organ. In the future, the project members intend to use the technology they have developed to study the dynamics and time dependence of the micro-structure in white matter. For example they will search for a finger print or a trace that a cognitive task imprints on white matter microstructure encoding new experiences in the wiring of the brain.
Another future direction is to characterize and understand micro-structural changes caused by different neurodegenerative diseases, such as Alzheimer's or schizophrenia, in order to develop better diagnostic procedures for these and other devastating conditions.
Source: University College London
Read the full CONNECT Report here or view below
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