- Lectures / Webinars
- Genetic insights into the classification and treatment modalities of the cerebral palsies
Genetic insights into the classification and treatment modalities of the cerebral palsies
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ICNC2024
Symposia: Hidden Etiology of Cerebral Palsy: Shifting Paradigms In An Era of Molecular Genetics
Genetic insights into the classification and treatment modalities of the cerebral palsies
Biju Hameed
Cerebral palsy (CP) is the most common motor disability in childhood, but its association with single gene disorders has not been adequately characterized. A genetic contribution to CP risk was identified by the observation of higher CP risk in groups with higher consanguinity and increased familial risk for CP. Historically, neurogenetic disorders were thought to be rare causes of CP, but with the spread of new generation genetic testing techniques, it is increasingly recognized that they play an important role in the etiology of CP. Genetic factors have been identified in approximately one-third of people with CP.
Recent advances in molecular genetics, such as chromosomal microarray and next-generation sequencing, have revolutionized the understanding of etiology by classifying these disorders more precisely with a molecular cause. In this era of genomic medicine, remarkable tools offer clinicians and researchers exciting opportunities for detailed characterization of neurodevelopmental disabilities. Updating practice parameters to include indications for genetic testing and interpretation should be considered to provide clarity and guidance on how to classify CP given the evolving genetic landscape.
This talk aims to explore the genetic landscape of CP and how the genomic revolution has translated into classification and treatment modalities of CP.
Other Lectures in this Symposium
In-depth analysis of genetic testing in CP with illustrative case studies and a glimpse at the future anticipated developments
Practical aspects of doing genetic testing in CP - Tests available and when to do which one for efficient diagnosis
Prompt use of clinical phenomenology and radiological investigations for evaluation for an underlying etiology in cerebral palsy