Interactive Pediatric Neurology Case Presentation

Speakers: Mini Sreedharan; Prashant Jauhari; Snehal Shah
When: September 13, 2025
Time: 09:00 AM Eastern Time ( US/ Canada )

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Talk Details:

Dr Mini Sreedharan
Title: Still Waters, Hidden Currents”
clinical presentation featuring a young girl who suddenly developed a severe headache. What appeared to be an uncomplicated, benign finding evolved into a rare and urgent clinical scenario.
About Topic:
The clinical profile of an acute-onset headache and how it can mask significant intracranial dynamics. Recognition of intracranial pressure–driven headache features, evolving from benign to critical. Key neuroimaging clues that help distinguish this unusual “benign” condition when it behaves atypically—including insights on incidental findings and complications from otherwise silent lesions. Ethical and practical management dilemmas faced in such rare and evolving scenarios—balancing vigilance, intervention, and conservative monitoring.
Learning Objectives:
1.Build and refine your differential diagnosis for acute-onset headache in clinical practice.
2.Understand how headache characteristics change with shifts in intracranial pressure.
3.Identify critical neuroimaging signs that indicate when a benign lesion has taken a dangerous turn.
4.Navigate the therapeutic challenges presented by unexpected complications in presumed benign lesions.

Dr Prashant Jauhari
Title: Unveiling the Imposter in Neuroinflammation in a young boy
About Topic:
Central nervous system (CNS) involvement in Hemophagocytic Lymphohistiocytosis (HLH) presents a diagnostic challenge, often masquerading as infectious, autoimmune, or neoplastic neuroinflammatory disorders. HLH, a hyperinflammatory syndrome driven by excessive immune activation, can manifest primarily or secondarily with CNS involvement, sometimes preceding systemic symptoms or occurring in isolation. This diagnostic ambiguity delays targeted treatment, increasing the risk of irreversible neurological damage or death. The index case highlights the diagnostic odyssey of primary CNS HLH in a seven-year-old boy.
Learning Objectives:
1.CNS presentation in HLH may precede systemic features by years mimicking infections (CNS tuberculosis) and demyelination (multiple sclerosis) during the disease course.
2.Relapsing and treatment refractory disease course with demyelinating lesions with a hemorrhagic component warrants evaluation for HLH.
3.Genetic testing to exclude familial HLH should be considered, even when CNS-HLH appears to be triggered by infection.

Dr.Snehal Shah
Title: Episodic events Day and night: Tale with many twist
About topic:
PRRT2 is a known genetic cause for self-limited familial neonatal – infantile epilepsy- , Infantile convulsion with chreoathetosis (ICCA) paroxysmal kinesogenic dyskinesia (PKD) and hemiplegic migraine. . Voluntary movement triggering is prominent feature in adolescent and adult patients. We hereby report case of PRRT 2 mutation with unusual presentation of paraesthesia, abdominal pain and hypnogenic dyskinesias.
Learning Objective:
1.Varied presentation of this not so uncommon genetic syndrome
2.Early diagnosis will prevent unnecessary investigation and treatment
3.Highlights semiology of episodes and EEG features which helps to differentiate it from usual childhood epilepsy syndrome.
4.Delineates clinical profile of these patients