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- Mechanism of SUDEP; Results from recent clinical and basic sciences research
Mechanism of SUDEP; Results from recent clinical and basic sciences research
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ICNC2024
Symposia: Addressing The Restrictions and Mortality In The Lives of Children With Epilepsy.
Mechanism of SUDEP; Results from recent clinical and basic sciences research
Helen Cross
Symposia: Addressing The Restrictions and Mortality In The Lives of Children With Epilepsy.
Mechanism of SUDEP; Results from recent clinical and basic sciences research
Helen Cross
Though considerable progress has been made in the understanding of SUDEP etiology and pathogenesis of SUDEP are not fully understood. The presence and frequency of GTCs is the most important risk factor for SUDEP. Previously reported risk factors such as young age of epilepsy onset, longer duration of epilepsy, intellectual disability, and structural etiologies were found not to be associated with SUDEP after adjustment for GTC frequency. Infants who were small for gestational age and those with an Apgar score of 0-6 compared to 9-10 at 10 minutes had a three-fold increase in SUDEP risk. Genetic factors may be found in approximately 30-50% of patients who die of SUDEP on post-mortem testing. Both epilepsy-related genes and cardiac genes may be implicated in SUDEP deaths. Although not fully understood, underlying genetic risk factors may increase SUDEP risk through different mechanisms, such as autonomic dysfunction (i.e., reduced heart rate variability) and/or cardiorespiratory dysfunction (i.e., the gene may cause concomitant arrhythmia).
This interactive talk will discuss the recent advances in uncovering mechanisms of SUDEP based on basic science and clinical research, especially neurotransmitters (e.g., adenosine, serotonin, etc.), respiratory function (e.g., ictal apnea/hypoxemia including central mechanisms and diaphragmatic paralysis), and autonomic dysfunction and cardiac changes in patients with epilepsy.
Other lectures related to this symposium
Can we prevent SUDEP
Mortality in CWE: Analyzing the prevalence and risk factors
Restrictions in the lives of Children with Epilepsy: Finding the right balance