Ingrid Tein

Staff Neurologist,
Professor Emeritus, Hospital for Sick Children, Toronto

Dr. Ingrid Tein is founder and Director of the Neurometabolic Clinic, Investigational Unit and Research Laboratory since 1991, Staff Neurologist in the Division of Neurology, Senior Scientist Emeritus in the Genetics and Genomic Biology Program in the Research Institute at the Toronto Hospital for Sick Children and Professor Emeritus in the Dept. of Pediatrics and Dept. of Laboratory Medicine and Pathobiology at the University of Toronto. Dr. Tein directs the Neurometabolic Clinic for the investigation and treatment of children with fatty acid oxidation, mitochondrial, and peroxisomal disorders and cofactor-responsive epilepsies. She conducts prospective, cross-over cofactor trials in children with mitochondrial disorders and the ergometric investigation of metabolic myopathies. Her Laboratory focuses on the biochemical and molecular investigation of genetic fatty acid oxidation defects including the carnitine/organic cation transporter family and development of in vitro disease models to understand underlying pathophysiological mechanisms. She has identified novel clinical and biochemical phenotypes and genotypes, developed new diagnostic screening tests, and developed novel treatment strategies aimed at bypassing or correcting the specific metabolic block, which have decreased long-term morbidity and mortality in affected children and have been implemented internationally. She founded the Neurometabolic Fellowship program and was Director of the Annual Barsky Mitochondrial Lectureship (1996-2021). She has supervised over 50 trainees in Neurometabolic Diseases which has led to the establishment of new Neurometabolic programs in Canada, US, Europe, Middle East and Oceania. She is author of over 170 original peer-reviewed articles and reviews and has given over 400 invited talks (191 internationally). She was Co-Scientific Director of the Canadian Mitochondrial Network and Director of the Clinical Research and Therapeutic Discovery Pillar. She served on the International Child Neurology Association (ICNA) Executive Board (2002-2022) and as President of the ICNA (2014-2018) and is recipient of multiple awards including the ICNA Frank Ford Senior Investigator Award 2024 and multiple teaching awards.