Oestrogen and neuroprotection in TBI

Dr GatsonIn a study presented at Experimental Biology 2012 in San Diego CA, Dr Joshua Gatson and his team from the University of Texas, Southwestern Medical Center, Dallas demonstrates for the first time the anti-inflammatory and antioxidant capabilities of estrone after traumatic brain injury. The study, conducted in male rats, compared 0.5 mg of estrone to a placebo, both given 30 minutes after the injury. It demonstrated that estrone is involved in promoting brain-derived neurotrophic factor (BDNF), which promotes cell survival. Oestrone was administered withing 30 minutes of brain injury and resulted in an increase in BDNF, suggesting that the drug given shortly after injury, could potentially increase repair mechanism.

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Brain-derived neurotrophic factor mediates the neuro-protective effects of estrone after brain injury. J.W. Gatson, J. Simpkins, J. Wigginton, M-M. Liu, S. Wolf and J. Minei. Univ. of Texas Southwestern Med. Ctr. and Univ. of North Texas Hlth. Sci. Ctr. http://experimentalbiology.org
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