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Neuropathogenesis and Neurologic Manifestations of the Coronaviruses in the Age of Coronavirus Disease 2019

March 29, 2021 News ICNA
This narrative review from JAMA Neurology summarize available information regarding coronaviruses in the nervous system, identify the potential tissue targets and routes of entry of SARS-CoV-2 into the central nervous system, and describe the range of…

Zolgensma Benefits Observed in Presymptomatic SMA Patients

March 28, 2021 News ICNA
According to research presented at the 2021 Muscular Dystrophy Association (MDA) Virtual Clinical and Scientific Conference, on the SPR1NT trial Children with SMA treated with onasemnogene abeparvovec-xioi (Zolgensma®; Novartis) prior to the onset of…

"Cell Polarity" gene mutations in Tourette disorder

March 20, 2021 News ICNA
In the largest DNA sequencing study of Tourette Disorder (TD) to date, UC San Francisco researchers and their collaborators have unearthed new data suggesting a potential role for disruptions in cell polarity in the development of this condition. The…

Mitochondrial defects may lead to Autism Spectrum Disorder

March 20, 2021 News ICNA
Researchers at Children's Hospital of Philadelphia (CHOP) have demonstrated that autism spectrum disorder (ASD) may be caused by defects in the mitochondria of brain cells. The findings were published online by the Proceedings of the National Academy of…