Phenotypic and genetic spectrum in children with SCN8A-related disorders

Topic: Navigating MOGAD Landscape: Demyelination With Many Faces
Lecturers: Deying Liu (Speaker/Moderator); Chunhui Hu (Speaker/Expert Faculty); Xiaoxia Lin (Expert Faculty)
When: Saturday, 16 August 2025
Time: 09:00 AM Eastern Time ( US/ Canada )

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SCN8A-related disorders are associated with SeLIE, DEE, etc. This session will focus on the genetic and phenotypic diversity of SCN8A-related disorders in China, highlighting the phenotype-genotype correlation. Key topics will include the consensus on the diagnosis, genetic counseling, the five phenotypes of SCN8A-related disorders, comorbidities, available resources for families, and treatment and management strategies. Additionally, unresolved challenges and future strategies will be discussed.

⁠Learning Objectives:

o Gain a comprehensive understanding of the genetic and phenotypic spectrum of SCN8A-related disorders in China.
o Explore the phenotype-genotype correlation and its implications for diagnosis and counseling.
o Review treatment and management strategies for SCN8A-related disorders.
o Identify ongoing challenges and future research directions.