A retrospective study on 71 children with refractory epilepsy looking at the effect of concomitant AED use on the efficacy of the ketogenic diet (KD), has suggested that Lamotrigine used alongside significantly reduced the efficacy of the diet (van der LouW et al., 2015). The study was performed by van der LouW and colleagues at Erasmus University Hospital Sophia Children's Hospital, Rotterdam and published in the journal Seizure on 21 September 2015. The study included children aged 0-18 yrs. who were started on KD between 2008-2014 and were on the diet for at least 3 months...

PURPOSE:To analyze the adverse events (AEs) significantly associated with levetiracetam (LEV) therapy through a meta-analysis of all available double-blind, randomized placebo-controlled trials (RCTs), performed in any age, gender, ethnic background and disease. General tolerability and study withdrawals due to AEs associated with LEV treatment were also investigated. In addition, a dose-effect responses relationship for all variables was assessed. METHODS:RCTs were identified searching Medline (PubMed), Embase and Cochrane CENTRAL for the words "Levetiracetam" and "randomized controlled trial", with different search strategies, setting the limits "humans" and "English". Very common and common AEs according to the summary of...