Aim The aim of this study was to examine whether vigabatrin treatment had caused visual field defects (VFDs) in children of school age who had received the drug in infancy. Method In total, 35 children (14 males, 21 females; median age 11y, SD 3.4y, range 8–23y) were examined by static Humphrey perimetry, Goldmann kinetic perimetry, or Octopus perimetry. The aetiologies of infantile spasms identified were tuberous sclerosis (n=10), other symptomatic causes (n=3), or cryptogenic (n=22). Results Typical vigabatrin-attributed VFDs were found in 11 out of 32 (34%) children: in one out of 11 children...

Dev Med Child Neurol. 2012 Nov;54(11):1018-24. doi: 10.1111/j.1469-8749.2012.04404.x. Epub 2012 Aug 27. Septo-optic dysplasia in childhood: the neurological, cognitive and neuro-ophthalmological perspective. Signorini SG, Decio A, Fedeli C, Luparia A, Antonini M, Bertone C, Misefari W, Ruberto G, Bianchi PE, Balottin U. Source Centre of Child Neuro-ophthalmology, Unit of Child Neurology and Psychiatry, C. Mondino National Institute of Neurology, IRCCS, Pavia;  Department of Ophthalmology, IRCCS San Matteo Hospital, Pavia  University of Pavia, Pavia, Italy.