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Childhood Status Epilepticus and Epilepsy Determinants of Outcome (seed): A Cohort Protocol

Childhood Status Epilepticus and Epilepsy Determinants of Outcome (SEED): A cohort protocol

Objective: To perform deep phenotyping of childhood status epilepticus (SE) and determine the clinical and genomic predictors of outcome in a large cohort study. Methods: We will enroll up to ~1800 children, ages 30 days to < 15 years, with SE from three hospitals in Kano, Nigeria over 24 months. SE diagnosis and treatment will be based upon a standardized protocol implemented at the three participating hospitals. Epileptologists will phenotype SE, using standardized criteria, including point-of-care EEG-video, MRI, and detailed medical and family history, and standard laboratory tests. Blood for DNA extraction will be obtained upon enrollment. Genomic risk factors for SE-associated mortality, morbidity, benzodiazepine-resistant SE, and development of epilepsy will be studied via genome-wide association studies (GWAS). GWAS, identifying SNPs associated with poor outcomes, and candidate gene analyses will be performed using the H3Africa Illumina array of ~2.3 million SNPs, enriched for common African variants, with PCA-matched population controls from H3Africa collaborators. Results: The outcomes measures will include the clinical and genomic predictors of (1) short-term SE-associated mortality, (2) benzodiazepine-resistant SE, (3) long-term SE-associated mortality and morbidity, (4) recurrent SE, and (5) development of epilepsy after surviving first seizure as SE. Others are detailed EEG-video and MRI findings associated with SE.

Conclusions: SEED will provide the most detailed-to-date characterization of childhood SE in sub-Saharan Africa, as well as significant insights into the clinical and genomic predictors of SE-associated outcomes, including the development of epilepsy. Funding: NIH1R01 NS118483

Umar Abba Sabo
Bayero University Kano
Nigeria

Edwin Trevathan
Vanderbilt University Medical Centre/ VIGH
United States

Michele Ramsay
University of Witwatersrand
South Africa

Mansurah Abdulaziz
Bayero University Kano
Nigeria

Halima Adamu
Aminu Kano Teaching Hospital
Nigeria

Aminu Taura Abdullah
Bayero University Kano
Nigeria

Aliyu Ibrahim
Bayero University Kano
Nigeria

Maggie Marsh-Nation
Baptist College of Health Sciences
United States

Donna Ingles
Vanderbilt University Medical Center
United States

Angela Paolucci
VUMC
United States

Abubakar Yakasai
Aminu Kano Teaching Hospital
Nigeria

Yasir Sani
Aminu Kano Teaching Hospital
Nigeria

Sani Wada
Aminu Kano Teaching Hospital
Nigeria

Muhammad Umar
Aminu Kano Teaching Hospital
Nigeria

 


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