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A Multicentre Study of Radiologically Isolated Syndrome In Children: Can We Predict The Course?

Objectives: To evaluate demographic, clinical and radiological characteristics of Radiologically Isolated Syndrome (RIS) in children and to describe laboratory and imaging features associated with subsequent clinical event or radiologic evolution.

Methods: Demographic, clinical and radiological characteristics of children with MRI findings fulfilling the revised 2017 McDonald Criteria for dissemination in space but without symptoms of demyelinating disease were retrospectively analyzed.

Results: There were total 69 patients (38 girls,31 boys). The median age at index MRI was 16.6 years, and median follow-up, 21 months (1-96 months). The most common reason for neuroimaging was headache (55%). A first clinical event occurred in 14/69 (20.3%) children in median 11 (1-35) months, in 14/69 (20.3%) of patients meeting Mc Donald 2017 criteria and 6/28 (21.4%) of those meeting Barkhof criteria. New lesions on imaging developed in 34/54 (62.96%) children in median 6 (1-18) months. Oligoclonal bands (OCB) in cerebrospinal fluid (CSF) were associated with an increased risk of clinical (p<0.05) and radiologic (p=0.022) evolution.

Conclusion: CSF OCB positivity was the only predictor of subsequent clinical or radiologic evolution. Children with CSF OCB positivity should be closely followed-up for conversion to MS although the optimal disease modifying treatment (DMT) for such cases is unknown. Longitudinal follow-up and controlled treatment trials are needed to define the preventive role of DMT in high-risk children and the real risk of conversion to MS.

Deniz Yılmaz

Turkey

Serap Teber

Turkey

Pembe Gültutan

Turkey

Miraç Yıldırım

Turkey

Ömer Bektaş

Turkey

Defne Alikılıç

Turkey

Mesut Güngör

Turkey

Bülent Kara

Turkey

İbrahim Öncel

Turkey

Tuğçe Damla Dilek

Turkey

Sema Saltık

Turkey

Seda Kanmaz

Turkey

Sanem Keskin Yılmaz

Turkey

Hasan Tekgül

Turkey

Dilek Çavuşoğlu

Turkey

Pakize Karaoğlu

Turkey

Ünsal Yılmaz

Turkey

Sibğatullah Ali Orak

Turkey

Olcay Güngör

Turkey

Banu Anlar

Turkey

 


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