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Evaluation of Pediatric Cases With Pseudotumor Cerebri Syndrome: A National Multicenter Study

This study, it was aimed to make an evaluation in the follow-up and treatment of cases with pseudotumor cerebri syndrome (PTC).

Data was collected from 21 centers in Turkey based on retrospective records, patients with pseudotumor cerebri according to Modified Dandy Criteria and followed for at least 3 months between January 2010 and January 2022 were included. Complaints were examined in terms of demographic data, clinical, radiological findings, treatment options, and follow-up.

688 children were diagnosed with PTC, the mean age was 134.1 months at the onset. In a lumbar puncture, the mean opening pressure was 380 mm-H2O. The majority of girls (58.8%) had, 51.6% primary PTC in diagnostic classification. The obesity rate was 36.6%. The most common symptom was headache (78%). 52 cases (%7.7) were asymptomatic. In magnetic resonance imaging %61 was normal, %9.9 globe flattening,% 7.9 optic nerve tortuosity, 6.1% sinus vein stenosis, and 4.2% empty sella. Treatment was applied medically in order acetazolamide (618/688) as the first choice, topiramate (167/688), steroids (49/688), and furosemide (18/688). Surgical treatment applied to 4.3% of patients: Shunt operations 17/30, optic nerve sheath fenestration 11/30. The mean time to remission of symptoms was 53.5 days during a mean15.9 month follow-up period. while the median time to remission for papilledema was 75.5 days. 76.7% of the patients were in remission, and 10.7% of them were reported to be in relapse.

PTC is mostly idiopathic, can recur, and lead to vision loss. Early diagnosis and effective treatment are important to prevent vision loss.

Mehmet Canpolat
Erciyes University Faculty of Medicine, Department of Pediatric Neurology

Ayten Güleç
Erciyes University Faculty of Medicine, Department of Pediatric Neurology

Hüseyin Per
Erciyes University Faculty of Medicine, Department of Pediatric Neurology

İlknur Erol
Baskent University Adana Dr. Turgut Noyan Application and Research Center

Sermin Özcan
Marmara University Medical University, Department of Pediatric Neurology

Nihal Yıldız
Karadeniz Technical University Faculty of Medicine, Department of Pediatric Neurology

Cemile Büşra Ölçülü
Ege University Faculty of Medicine, Department of Pediatric Neurology

Nihal Olgaç Dündar

Çetin Okuyaz
Mersin University Faculty of Medicine, Department of Pediatric Neurology

Yasemin Özkale
Baskent University Adana Dr. Turgut Noyan Application and Research Center

Gülcan Akyüz Yücel
Marmara University Medical University, Department of Pediatric Neurology

Elif Acar Arslan

Seda Kanmaz
Ege University Faculty of Medicine, Department of Pediatric Neurology

Pınar Gençpınar
İzmir Katip Celebi University, SBU Tepecik Training and Research Hospital, Department of Pediatric Neurology

Selcan Öztürk

Serdal Güngör
İnönü University Medical University, Department of Pediatric Neurology

Ahmet Sami Güven
Necmettin Erbakan University, Faculty of Medicine Meram, Department of Pediatric Neurology

Betül Kılıç
Medipol University Faculty of Medicine, Department of Pediatric Neurology

Filiz Mıhçı
Ondokuz Mayıs University Faculty of Medicine, Department of Pediatric Neurology

İsmail Hakkı Akbeyaz
Marmara University Medical University, Department of Pediatric Neurology

Merve Öztürk
Kocaeli University Faculty of Medicine, Department of Pediatric Neurology

Mine Çiğdem Senoğlu
Gulhane training and research hospital, Department of Pediatric Neurology

Semra Hız Kurul

Merve Yavuz

Hülya İnce
VM Medical Park Samsun Hospital, Department of Pediatric Neurology

Şeyda Besen
Baskent University Adana Dr. Turgut Noyan Application and Research Center

Gülten Öztürk

Tülay Kamaşak
Karadeniz Technical University Faculty of Medicine, Department of Pediatric Neurology

Hepsen Mine Serin
Ege University Faculty of Medicine, Department of Pediatric Neurology

Müge Baykan
İzmir Katip Celebi University, SBU Tepecik Training and Research Hospital

Meltem Çobanoğulları Direk

Bilge Özgör
İnönü University Medical University, Department of Pediatric Neurology

Burcu Çalışkan
Necmettin Erbakan University, Faculty of Medicine Meram, Department of Pediatric Neurology

Hüseyin Tan
Atatürk University Faculty of Medicine, Department of Pediatric Neurology

Çisil Çerçi Kubur
Celal Bayar University Faculty of Medicine, Department of Pediatric Neurology

Dilara Füsun İçağasıoğlu

Murat Özkale

Yasemin Topçu
Medipol University Faculty of Medicine, Department of Pediatric Neurology

Merve Hilal Dolu
Ondokuz Mayıs University Faculty of Medicine, Department of Pediatric Neurology

Mesut Güngör
Kocaeli University Faculty of Medicine, Department of Pediatric Neurology

Bülent Unay
Gulhane training and research hospital, Department of Pediatric Neurology

Döndü Ülker Üstebay
Dokuz Eylul University Medical University, Department of Pediatric Neurology

Pakize Karaoğlu
İzmir Behçet Uz Children Hospital, Department of Pediatric Neurology

Hakan Gümüş
Erciyes University Faculty of Medicine, Department of Pediatric Neurology

Turkish Pediatric Pseudotumor Cerebri Study Group Collabora Study Group Collaboration

 


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