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Efficacy of Teleconsultation-Based Rehabilitation In Children With Landry Guillain Barre Syndrome: An Open Label Randomized Controlled Trial (tele Rehab Lgbs Trial).

Objective: To evaluate the feasibility and efficacy of teleconsultation-based rehabilitation versus standard care in Landry Guillain barre syndrome measured with medical research council (MRC) and Hughes score. Method: A pragmatic, prospective, parallel open label randomized controlled trial. Randomization: Computer generated block randomization. Intervention: Standard care (group A) and teleconsultation-based rehabilitation (Group B). Primary outcome measured with MRC and Hughes score at 12- and 24-weeks post-discharge. Results: A total of 50 children were randomized. The mean age was 6.4±3.3 years, 29(58%) were boys. The MRC (median, IQR), and Hughes score (median, IQR) at admission in group A and B was 24(IQR (7-31) and 5 (IQR 4-5) ; and 18(IQR 9-24) and 4(IQR 4-5) (p value =0.43). In group A and B, 8 and 11 children received mechanical ventilation, and 72% were AMAN variant. At discharge, median MRC score in group A and B was 34(28-41) and 30 (25-43) (p value=0.31). At 12 weeks, 48 (96%) children were followed up; median MRC score in group A and B was 48(IQR 44-54) and 52 (IQR 46-60) (p value=0.08). Median Hughes score in group A and B was 2 IQR (1-3) and 2 IQR (0.5-3) (p value=0.56). Compliance to tele-consultation was 96% in group B. At 24 weeks, 36(72%) children were followed up, median Hughes score in group A and B was 1 (IQR 0-2) and 0.5 (IQR 0-1.25) (p value=0.22). Conclusion: Tele-consultation-based rehabilitation was feasible with high compliance rate. MRC and Hughes score at 12 and 24 weeks were similar in both groups.