Journal Watch

karenskjeiKaren L. Skjei, M.D.
Assistant Professor,
Department of Neurology Co-Director,
Epilepsy Surgery Program Director,
Epilepsy Monitoring Unit,
Norton Children's Hospital

Dr. Karen Skjei is an assistant professor of Neurology and Pediatrics at the University of Louisville. She completed her undergraduate studies at Duke University, and her medical education at the University of California at San Francisco School of Medicine. She completed a residency in Pediatrics and a fellowship in Child and Adolescent Neurology at the Mayo Clinic in Rochester, New York. She completed a fellowship in Neurophysiology and Epilepsy at the Children’s Hospital of Philadelphia. Dr Skjei is currently Editor of the ICNApedia Journal Watch

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ICNA
ICNA
Updated December 14, 2015 10160 0
PLoS Computational Biology Dec 10, 2015
Temporal lobe epilepsy (TLE) is a prevalent neurological disorder resulting in disruptive seizures. In the case of drug resistant epilepsy resective surgery is often considered. This is a procedure hampered by unpredictable success rates, with many patients continuing to have seizures even after surgery.
 
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ICNA
ICNA
Updated December 14, 2015 10735 0
Headache: The Journal of Head and Face Pain
Migraines can be triggered by a variety of factors, including stress, sleep disruption, noise, odors, and diet. The recent discovery that the TRPA1 ion channel transduces oxidative stress and triggers neurogenic inflammation suggests that oxidative stress may be the common denominator underlying migraine triggers. The findings of a new Headache review indicate that many of these factors converge on a common pathway involving oxidative stress.
 
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ICNA
ICNA
Updated November 11, 2015 10637 0
Acad Emerg Med. 2015 Nov;22(11)
In a study published online in the journal Academic Emergency Medicine, researchers from the Departments of Emergency Medicine at Orlando Regional Medical, Arnold Palmer Hospital for Children ,Orlando, The Children’s Hospital of Philadelphia and the Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania , Philadelphia examined the performance of serum glial fibrillary acidic protein (GFAP) in detecting traumatic intracranial lesions on computed tomography (CT) scan in children and youth with mild and moderate traumatic brain injury (TBI) and assessed its performance in trauma control patients without head trauma.
 
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ICNA
ICNA
Updated November 11, 2015 8334 1
Ann Neurol. 2015 Oct 27
In a study published online in Annals of Neurology, researchers from the University of South Australia in Adelaide have identified mutations in GATOR1 complex as the most significant cause of familial focal epilepsy identified to date.
 
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ICNA
ICNA
Updated October 19, 2015 10123 0
Seizure. doi:10.1016/j.seizure.2015.09.007
A retrospective study on 71 children with refractory epilepsy looking at the effect of concomitant AED use on the efficacy of the ketogenic diet (KD), has suggested that Lamotrigine used alongside significantly reduced the efficacy of the diet (van der LouW et al., 2015). The study was performed by van der LouW and colleagues at Erasmus University Hospital Sophia Children's Hospital, Rotterdam and published in the journal Seizure on 21 September 2015. The study included children aged 0-18 yrs. who were started on KD between 2008-2014 and were on the diet for at least 3 months...
 
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ICNA
ICNA
Updated September 24, 2015 12293 1
Eur J Paediatr Neurol. 2015 Jul 18
In a long term retrospective study on children with refractory Childhood Absence Epilepsy (CAE), published in EJPN, Franzoni and colleagues (Franzoni et al., 2015) report a higher incidence of cognitive impairment in children with longer duration of childhood absence epilepsy indicating the not so benign nature of this condition.
 
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ICNA
ICNA
Updated September 18, 2015 8155 0
Seizure. 2015 Sep;31:49-55
PURPOSE:To analyze the adverse events (AEs) significantly associated with levetiracetam (LEV) therapy through a meta-analysis of all available double-blind, randomized placebo-controlled trials (RCTs), performed in any age, gender, ethnic background and disease. General tolerability and study withdrawals due to AEs associated with LEV treatment were also investigated. In addition, a dose-effect responses relationship for all variables was assessed. METHODS:RCTs were identified searching Medline (PubMed), Embase and Cochrane CENTRAL for the words "Levetiracetam" and "randomized controlled trial", with different search strategies, setting the limits "humans" and "English". Very common and common AEs according to the summary of...
 
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Epileptic Disorders
Epileptic Disorders
Updated September 22, 2014 11857 0
Epilepsies originating from the posterior cortex, namely the parieto-occipital lobes and the occipital border of the temporal lobe, account for the minority of focal epilepsies (Boesebeck et al., 2002), therefore, epilepsy surgery in the posterior cortex has been less extensively examined in the literature, relative to that for temporal or frontal lobe epilepsies. Most studies emphasize the difficulty in delineating the precise localisation of a posterior epileptogenic zone (EZ: the site of origin and of primary propagation of ictal discharges; Bancaud et al., 1970; Kahane et al., 2006) because of rather non-specific clinical seizure patterns (Bancaud,...
 
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The Lancet Neurology
The Lancet Neurology
Updated August 29, 2014 14715 0
Lancet Neurol 13 (8):844-54
The Personal View is published on the 40th anniversary of the Glasgow Coma Scale's introduction in a 1974 Lancet article*. Since this seminal publication, the Glasgow Coma Scale has provided a practical method for bedside assessment of impairment of conscious level, the clinical hallmark of acute brain injury. The paper's lead author is Professor Graham Teasdale, of the University of Glasgow, UK, one of the authors of the original paper introducing the scale. Professor Teasdale and colleagues examine the extent to which the original aspirations of the authors have been fulfilled, address some myths and misapprehensions about the scale,...
 
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Pediatric Neurology
Pediatric Neurology
Updated August 28, 2014 14077 1
Pediatr Neurol. 2014 May 29
BACKGROUND: Anti-N-methyl-d-aspartate (NMDA) receptor antibody encephalitis is becoming an increasingly recognized cause of encephalopathy in cases previously presumed to be viral encephalitis. Various manifestations of this disease include altered mental status, behavioral changes, seizures, and movement disorders. We have noted three distinct subtypes of this disease which appear to have differential responses to immunotherapies and differences in prognosis.
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