Page 280 - ILAE_Lectures_2015

ELIMINATION ROUTE(S) OF COMMENTS
HALF-LIFE ELIMINATION
(hours)
2445 (single) Hepatic metabolism Enzyme inducer
824 (chronic) Active metabolite Metabolic autoinduction
1030
Hepatic metabolism Sedative
3040 Active metabolite Tolerance

2060 Hepatic metabolism Sedative
Tolerance
57
Hepatic metabolism More rapid clearance in
1488 25% excreted unchanged children

72144 Not metabolised Limited absorption at high
Excreted unchanged doses
940
Hepatic metabolism by Half-life dependent on co-
717 glucuronidation medication

49 Hepatic metabolism Enzyme inducer
1230 25% excreted unchanged Sedative
Tolerance

Saturable hepatic Enzyme inducer
Metabolism Elimination half-life
concentration-dependent

Hepatic metabolism Enzyme inhibitor
Active metabolites Concentration-dependent
protein binding
Hepatic metabolism

Mostly hepatic metabolism, Cognitive slowing, kidney
with renal excretion. No stones, weight loss.
active metabolites Clearance increased by