Page 279 - ILAE_Lectures_2015

Table 1. Pharmacokinetics of established antiepileptic drugs.

DRUG ABSORPTION PROTEIN
BINDING
(BIOAVAILABILITY) (% bound)
7080
CARBAMAZEPINE Slow absorption
(7585%) 8790

CLOBAZAM Rapid absorption 8090
(90100%)
0
CLONAZEPAM Rapid absorption
(8090%) 0

ETHOSUXIMIDE Rapid absorption
(9095%)

GABAPENTIN Rapid initial absorption

LAMOTRIGINE Rapid absorption 5055
PHENOBARBITAL (95100%) 4854

Slow absorption
(95100%)

PHENYTOIN Slow absorption 9093
(8590%)

SODIUM VALPROATE Rapid absorption 8892

TIAGABINE Rapid absorption 8796
TOPIRAMATE Rapid absorption 15