Page 27 - ILAE_Lectures_2015

opioid neuropeptide that is normally present in the granule cells and in the terminal fields of the
mossy fibres as well as with labelling for zinc transporter 3 (ZnT3)54.

(iii) Widespread changes in association with hippocampal sclerosis in TLE. Pathology may
extend beyond the hippocampus, involving adjacent structures (as well as regions connected with
the hippocampus). These additional pathologies (usually neuronal loss, gliosis) may be relevant
to seizure onset (and epileptogenesis), seizure networks, associated co-morbid features including
neuropsychological impairment and poor outcome following surgical treatment.