Page 23 - ILAE_Lectures_2015

In many centres surgical tissues are sent immediately, fresh to the laboratory, to allow the
opportunity for appropriate freezing, fixing and banking of tissue samples for both diagnostic
and research purposes31. Common specimens include lobectomies (temporal or frontal),
hippocampectomies or lesionectomies. Common pathologies recognised are presented in the
Table below; the incidence may vary according to the age group included, with malformations
more common in paediatric cohorts. In some resections (particularly if ‘MRI-negative’) no-
specific lesion is identified and gliosis or microgliosis may be the only histology finding. In other

cases, a double or dual pathology is found.

Year
Region
Age of patients
Mean/range
Number of cases
Focal dysplasias
Vascular
malformations
Tumours
Hippocampal
sclerosis
Atrophic lesion
(Old infarcts/
traumatic lesions/
scars)
Inflammatory
pathology
Gliosis or no
pathology
Dual pathology
cases (HS+lesion)
Other

2002 Grenoble All ages 327 18% 28.70% 25.90% 5% 1.2% 15.50% 5%
2008 Paediat‐ 2.7% 6.30% 13.8%
2009 Multi‐ ric 413 42.4% 1.5% 19.1% 6.50% 9.9% 3.6
centre All ages 1.60% 6.80% 5% %
2010 German 4512 12.70% 6% 27.30% 35.20% 5.20%
epilepsy All ages
register 435 52.90% 11.70% 17% 22.80%
Beijing