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Table 2. Choice of AED for common epilepsy syndromes.
Adjunctive AEDs to avoid
(may worsen
Epilepsy syndrome First-line AEDs AEDs seizures)
Childhood absence epilepsy or other Ethosuximide Ethosuximide Carbamazepine
absence syndromes Lamotrigine Lamotrigine Gabapentin
Sodium Sodium valproate Oxcarbazepine
valproate
Phenytoin
Pregabalin
Tiagabine
Vigabatrin
Juvenile absence epilepsy or other absence Ethosuximide Ethosuximide Carbamazepine
Lamotrigine Gabapentin
syndromes Lamotrigine Sodium valproate Oxcarbazepine
Sodium Phenytoin
Pregabalin
valproate Tiagabine
Vigabatrin
Juvenile myoclonic epilepsy Lamotrigine Lamotrigine Carbamazepine
Levetiracetam
Sodium Levetiracetam Gabapentin
valproate
Topiramate Sodium valproate Oxcarbazepine
Topiramate Phenytoin
Pregabalin
Tiagabine
Vigabatrin
Epilepsy with generalised tonic-clonic Carbamazepine Clobazam
seizures only Lamotrigine Lamotrigine
Oxcarbazepine Levetiracetam
Sodium Sodium valproate
valproate Topiramate
Idiopathic generalised epilepsy Lamotrigine Lamotrigine Carbamazepine
Sodium Levetiracetam Gabapentin
valproate Sodium valproate Oxcarbazepine
Topiramate Topiramate Phenytoin
Pregabalin
Tiagabine
Vigabatrin
Benign epilepsy with centrotemporal Carbamazepine Carbamazepine
spikes Lamotrigine Clobazam
Levetiracetam Gabapentin
Oxcarbazepine Lamotrigine
Sodium Levetiracetam
valproate Oxcarbazepine
Sodium valproate
Topiramate
