Lennox-Gastaut syndrome and Doose syndrome [ICNApedia]

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====== Lennox-Gastaut syndrome and Doose syndrome ======
^ Feature                                               ^ Lennox-Gastaut Syndrome                                                                  | Doose Syndrome                                                                                                      |
|                                                       |                                                                                          |                                                                                                                     |
| Main seizures                                         | Tonic; atonic and atypical absences                                                      | Myoclonic, atonic and myoclonic-atonic                                                                              |
|                                                       |                                                                                          |                                                                                                                     |
| Tonic seizures                                        | Common and characteristic, diurnal and nocturnal                                         | Probably exclusion criterion (nocturnal tonic seizures are accepted by some authors)                                |
|                                                       |                                                                                          |                                                                                                                     |
| Tonic drop attacks                                    | Common                                                                                   | Incompatible                                                                                                        |
|                                                       |                                                                                          |                                                                                                                     |
| Atypical absences                                     | Common also occurring independently of other seizures                                    | Uncommon, they usually accompany myoclonic or atonic episodes                                                       |
|                                                       |                                                                                          |                                                                                                                     |
| Developmental abnormalities before onset of seizures  | Common                                                                                   | Exceptional if any                                                                                                  |
|                                                       |                                                                                          |                                                                                                                     |
| Aetiology                                             | Symptomatic or possibly symptomatic (idiopathic cases are accepted by some authorities)  | Idiopathic1 (although symptomatic or possibly symptomatic cases are included in the ILAE classification of 198912)  |
|                                                       |                                                                                          |                                                                                                                     |
| Genetic predisposition                                | None                                                                                     | Common                                                                                                              |
|                                                       |                                                                                          |                                                                                                                     |
| Development from West syndrome                        | Common                                                                                   | Incompatible                                                                                                        |
|                                                       |                                                                                          |                                                                                                                     |
| EEG background                                        | Abnormal by rule                                                                         | Usually normal particularly at onset                                                                                |
|                                                       |                                                                                          |                                                                                                                     |
| EEG episodic fast activity and rapid spikes           | Common and often characteristic                                                          | Exceptional and mainly in sleep                                                                                     |
|                                                       |                                                                                          |                                                                                                                     |
| EEG slow generalised spike wave                       | Usually                                                                                  | Usually 2–3 Hz                                                                                                      |
|                                                       |                                                                                          |                                                                                                                     |
| Prognosis                                             | Commonly bad                                                                             | Commonly relatively good                                                                                            |
|                                                       |                                                                                          |                                                                                                                     |