Feature | Lennox-Gastaut Syndrome | Doose Syndrome |
| | |
Main seizures | Tonic; atonic and atypical absences | Myoclonic, atonic and myoclonic-atonic |
| | |
Tonic seizures | Common and characteristic, diurnal and nocturnal | Probably exclusion criterion (nocturnal tonic seizures are accepted by some authors) |
| | |
Tonic drop attacks | Common | Incompatible |
| | |
Atypical absences | Common also occurring independently of other seizures | Uncommon, they usually accompany myoclonic or atonic episodes |
| | |
Developmental abnormalities before onset of seizures | Common | Exceptional if any |
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Aetiology | Symptomatic or possibly symptomatic (idiopathic cases are accepted by some authorities) | Idiopathic1 (although symptomatic or possibly symptomatic cases are included in the ILAE classification of 198912) |
| | |
Genetic predisposition | None | Common |
| | |
Development from West syndrome | Common | Incompatible |
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EEG background | Abnormal by rule | Usually normal particularly at onset |
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EEG episodic fast activity and rapid spikes | Common and often characteristic | Exceptional and mainly in sleep |
| | |
EEG slow generalised spike wave | Usually | Usually 2–3 Hz |
| | |
Prognosis | Commonly bad | Commonly relatively good |
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Discussion