Seda Kanmaz, Sanem Yilmaz, Nihal Olgac Dündar, Ayse Aksoy, Mehmet Canpolat, Huseyin Per, Ilknur Erol, Hakan Gumus, Yasemin Ozkale, Selcan Ozturk, Dilara Ece Toprak, Ibrahim Oncel, Murat Ozkale, Elif Nurdan Mansur, Hepsen Mine Serin, Gulsen Ersoz, Seyda Besen, Gulen Gul Mert, Ayten Gulec, Sevim Sahin, Cemile Busra Olculu, Ayberk Selek, Serdar Pekuz, Gunce Basarir, Cagatay Gunay, Leman Tekin Orgun, Didem Bİcer, Zehra Filiz Kahraman, Deniz Yuksel, Meral Karadag, Erdem Simsek, Aycan Unalp , Nihal Yildiz, Meltem Cobanogullari Direk , Uluc Yis, Huseyin Tan, Cengiz Havali , Aydan Degerliyurt , Mesut Gungor , Ozlem Herguner , Elif Perihan Oncel , Olcay Unver , Hale Atalay Celik, Bilge Ozgor, Ali Cansu , Asli Kubra Atasever , Ayse Tosun, Olcay Gungor, Cetin Okuyaz, Selvinaz Edizer , Semra Hız , Esra Sarıgecili, Gokcen Oz Tuncer , Pinar Gencpinar, Unsal Yilmaz, Hasan Tekgul, Banu Anlar

Objectives: To present demographic, clinical, laboratory and prognostic data in a large group of children with ADEM and to investigate the role of anti-MOG antibodies in clinical findings and outcome. Methods: ADEM patients (n=245) from 24 centers diagnosed in 2010-2021were retrospectively evaluated with descriptive statistics. Duplicate cases were excluded. Results: The male/female ratio was 1.66:1, mean age at diagnosis was 6.33.8 (0.5-17.7) years. The most common findings on admission besides altered state of consciousness were fatigue (57.1%), headache (40.4%), and fever (39.6%). Serum anti-MOG antibodies were tested in 84 patients and 27 (32%) found positive by cell-based assay. Anti-MOG-positive patients were younger (5.12.7 vs. 7.13.4) and their blood white blood cell count was higher (15,1006,116/mm3 vs. 12,1685,830/mm3). Twenty-three (9.4%) patients had relapses. The final diagnoses and their anti-MOG antibody status is given in Table-1. Anti-MOG antibody positivity was not associated with need for intensive care unit, relapse, or recovery. Among the 172 patients with at least one-year follow-up, Glasgow Coma Score <10, need for intensive care unit, mechanical ventilation, and the presence of seizures on admission were associated with incomplete recovery [Modified Rankin Score (mRS)1 (n=26), epilepsy (n=20), (p<0.005)]. Only three patients (1,7%) remained dependent [mRS=3 (n=1), mRS=4 (n=2)] at one-year of follow-up. Conclusion: ADEM is usually monophasic with relapses in 10% of the patients. The overall prognosis is good, regardless of the anti-MOG antibody status. The clinical condition on admission appeared as the most important prognostic factor.
Keywords: Acute disseminated encephalomyelitis, anti-MOG antibodies

Seda Kanmaz
Ege University Medical Faculty
Turkey

Sanem Yilmaz
Ege University Medical Faculty
Turkey

Nihal Olgac Dündar
Izmir Katip Celebi University Faculty of Medicine
Turkey

Ayse Aksoy
Ondokuz Mayis University Medical Faculty
Turkey

Mehmet Canpolat
Erciyes University Medical Faculty
Turkey

Huseyin Per
Erciyes University Medical Faculty
Turkey

Ilknur Erol
Baskent University Faculty of Medicine, Adana Dr.Turgut Noyan Application and Research Center
Turkey

Hakan Gumus
Erciyes University Medical Faculty
Turkey

Yasemin Ozkale
Baskent University Faculty of Medicine, Adana Dr.Turgut Noyan Application and Research Center
Turkey

Selcan Ozturk
Erciyes University Medical Faculty
Turkey

Dilara Ece Toprak
Ege University Medical Faculty
Turkey

Ibrahim Oncel
Hacettepe University Medical Faculty
Turkey

Murat Ozkale
Baskent University Faculty of Medicine, Adana Dr.Turgut Noyan Application and Research Center
Turkey

Elif Nurdan Mansur
Erciyes University Medical Faculty
Turkey

Hepsen Mine Serin
Ege University Medical Faculty
Turkey

Gulsen Ersoz
Hacettepe University Medical Faculty
Turkey

Seyda Besen
Baskent University Faculty of Medicine, Adana Dr.Turgut Noyan Application and Research Center
Turkey

Gulen Gul Mert
Cukurova University Medical Faculty
Turkey

Ayten Gulec
Erciyes University Medical Faculty
Turkey

Sevim Sahin
Karadeniz Technical University Medical Faculty
Turkey

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