Page 309 - ILAE_Lectures_2015

Table 2. Paediatric maintenance dosages of antiepileptic drugs.

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Drug Usual total daily dosage Doses/day

(mg/kg/day)

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Acetazolamide 10–20 2

Carbamazepine 10–20 2/31

Clobazam 0.5–l.5 2

Clonazepam 0.1–0.3 2/3

Eslicarbazepine 15–30 2

Ethosuximide 15–35 2 (3)

Gabapentin 30–45 3

Lacosamide 2–8 2

Lamotrigine (a) 2–52 2
(b) 4–10

Levetiracetam 3050 2

Nitrazepam 0.5–l 2/3

Oxcarbazepine 2030 2

Perampanel 8–10 (possibly 12) mg/day total 1

Phenobarbitone 4–8 2

Phenytoin 4–83 2 (l)

Rufinamide 25354 2
Sodium valproate 20–40 25

Stiripentol 2535 2 (possibly 3)

Tiagabine 0.51.0 2/3
Topiramate 4–86 2

Vigabatrin 50–1007 2

Zonisamide 45 2 (possibly 3)

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1. The sustained release preparation (Tegretol Retard) may be given once or twice a day, depending on the timing of the seizures

2. Dose (a) is used when sodium valproate is being taken concurrently with lamotrigine; dose (b) is used with lamotrigine monotherapy or with
drugs other than valproate

3. Dose varies considerably depending on age; neonates frequently require total daily doses in excess of 10–15 mg/kg

4. When used with sodium valproate the total daily dose is usually 2025 mg/kg in children with a body weight of <30 kg; titration to the
maintenance dose also takes slightly longer

5. The sustained release preparation (Epilim Chrono) is usually given once a day

6. The starting dose should be 0.5 mg/kg/day

7. When treating partial seizures, the usual maintenance dose is usually 3050 mg/kg/day. When treating infantile spasms, the usual dose is
80100 mg/kg/day although lower doses may be effective; the maximum dose is 120150 mg/kg/day