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Sedation, dizziness and headache are the most commonly reported adverse effects, particularly
when doses are being increased. Tolerance often develops and the symptoms are frequently
self-limiting. These symptoms can usually be avoided by introducing the drug gradually.
Allergic skin rashes are extremely rare. Up to 10% of people taking vigabatrin develop a change
in mood, commonly agitation, ill temper and disturbed behaviour, depression or, more rarely,
paranoid and psychotic symptoms. Visual field defects have been associated with long-term

treatment with vigabatrin in up to 4050% of people and this limits the use of the drug to those
cases in which potential benefit outweighs risk.