Page 287 - ILAE_Lectures_2015

Table 4 (contd). Side effects of established antiepileptic drugs.

LAMOTRIGINE PHENOBARBITAL PHENYTOIN

* Drowsiness * Fatigue * Nystagmus
* Diplopia * Listlessness * Ataxia
* Headache * Tiredness
* Ataxia * Depression Anorexia
* Insomnia * Insomnia (children) Dyspepsia
* Tremor * Distractibility (children) Nausea
* Hyperkinesia (children) Vomiting
Nausea * Irritability (children) Aggression
Vomiting Depression
Aggression Aggression Drowsiness
Irritability Poor memory Headache
Decreased libido Paradoxical se
Impotence Megaloblastic
Folate deficiency Hypergylcaem
+ Neonatal haemorrhage Hypocalcaemi
Hypocalcaemia Osteomalacia
Osteomalacia + Neonatal haem

* Rash * Macropapular rash * Rash

Stevens-Johnson Syndrome Exfoliation * Acne

Toxic epidermal necrolysis Toxic epidermal * Gum hypertro

Liver failure necrolysis * Coarse facies

Aplastic anaemia Hepatotoxicity * Hirsutism

Pancytopenia Frozen shoulder Blood dyscras

Multi-organ failure Teratogenicity Lupus-like syn

Reduced serum

Pseudolympho

Peripheral neu

Stevens-Johns

syndrome

Dupuytren’s c

Hepatotoxicity

Teratogenicity

Above line: Dose-related; Below line: Idiosyncratic; *Commonest side effects; + M