Serum and Hippocampus Thiol / Disulfide Balance in the Hyperthermic Febrile Seizure Model in Rats

Objective: The aim of this study to determine the relationship between oxidative stress and febrile seizures by evaluating the oxidant/antioxidant balance in serum and hippocampus separately in rats. Materials and Methods: Thirty-six Sprague Dawley type male rats aged 22-30 days were included in this study. Six groups (n=36/6): were formed the control group, the Hyperthermic Group, the 0th, the 6th and the Complicated and, the Frequent Recurrent Febrile Convulsion Groups. Intracardiac blood was drawn and hippocampal tissue was removed after they were sacrificed. Thiol/Disulfide balance in the samples obtained was studied at serum and tissue level. Results were compared with appropriate statistical methods. Results: In the Native Thiol (NT) values measured and, compared to the Control Group, in the Hyperthermic Group at 0h FC Group, 6th hour FC Group, Complicated FC group and Frequent FC group was found to be significantly lower. A significant difference was found between the Frequent FC Group and the Hyperthermic FC group, 0th hour FC group, 6th hour FC group and the Complicated Group in terms of Disulfide, Disulfide/Native Thiol, Disulfide/Total Thiol values. While these parameters were found to be lower in the Frequent FC group, the Native Thiol/Total Thiol parameter was higher in the Frequently Recurring FC group. According to serum values, thiol/disulfide values studied at tissue level were found to be high in all groups Conclusion: It was observed that the oxidant/antioxidant balance was impaired in favor of oxidants in the hyperthermic group together with the FC groups.