Differentiating between CAE and JAE
- Age at onset of CAE is considered to be 2 to 13 years of age and for Juvenile Absence Epilepsy (JAE) to be 8 to 20 years of age; there is five years of overlap[1].
- Patients with JAE more often have GTCS and more frequently experience seizure-related injuries compared with patients with CAE
- Valproate can be considered as the drug of choice in men and lamotrigine as the first drug of choice in women with JAE.
1.
a
ILAE definition of the Idiopathic Generalized Epilepsy Syndromes: Position statement by the ILAE Task Force on Nosology and Definitions. Epilepsia. 2022 Jun;63(6):1475-1499. doi: 10.1111/epi.17236. Epub 2022 May 3.
[PMID: 35503716] [DOI: 10.1111/epi.17236] .
[PMID: 35503716] [DOI: 10.1111/epi.17236] .
2.
a
Historical trend toward improved long-term outcome in childhood absence epilepsy. Epilepsy Res. 2019 May;152:7-10. doi: 10.1016/j.eplepsyres.2019.02.013. Epub 2019 Feb 25.
[PMID: 30856420] [PMCID: 6573015] [DOI: 10.1016/j.eplepsyres.2019.02.013] .
[PMID: 30856420] [PMCID: 6573015] [DOI: 10.1016/j.eplepsyres.2019.02.013] .
3.
a
Long-term seizure outcome in patients with juvenile absence epilepsy; a retrospective study in a tertiary referral center. Seizure. 2014 Jun;23(6):443-7. doi: 10.1016/j.seizure.2014.03.002. Epub 2014 Mar 12.
[PMID: 24684814] [DOI: 10.1016/j.seizure.2014.03.002] .
[PMID: 24684814] [DOI: 10.1016/j.seizure.2014.03.002] .
Discussion