content:csf_protein

CSF protein reference values

Reported reference values for CSF total protein (g/L) in infants, children, and adults.
Age Mean ± SD[1](range) Range[2] Mean (range)[3]
Term newborn 0.40–1.20 0.63 (0.32–2.40) 0.901)(0.20–1.70)
0–1 week 0.77 ± 0.16 (0.45–1.09) 0.47 (0.27–0.65)
1–2 weeks 0.672)(0.52–1.20)
2–3 weeks 0.66 ± 0.163) (0.51–1.01) 0.20–0.804)
3–4 weeks 0.525) (0.26–0.88)
1–2 months 0.48 (0.17–0.63)
2–3 months 0.45 +/- 0.136) (0.24–0.65)
3–6 months 0.29 ± 0.04 (0.23–0.37) 0.15–0.457)
6–12 months 0.27 ± 0.07 (0.17–0.35)
1–16 years 0.22 ± 0.05 (0.16–0.31)
b From Soldin et al. (4). c From Klein and Marcy (5)

1 Age range, newborn to 1week
2 Age range, 0 to 2 weeks
3 Age range, 1 to 4 weeks
4 Age range: 0 to 4 weeks
5 Age range, 2 to 4 weeks
6 Age range, 1 to 3 months
7 Age range, 1 month to adult

1. a Statz A, Felgenhauer K. Development of the blood-CSF barrier. Dev Med Child Neurol. 1983 Apr;25(2):152-61. PMID : 6189754
2. a Soldin JS, Brugnara C, KC Gunter, JM. Hicks, eds. Pediatric reference ranges, 2nd ed. Washington: AACC Press, 1997:181pp
3. a Klein JO, Marcy SM. Bacterial sepsis and meningitis. In: Remington JS, Klein JO, eds. Infectious diseases of the fetus and newborn infant, 4th ed. Philadelphia: WB Saunders, 1995:835– 90.
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