Introduction: Autonomic nervous system regulates the vital functions of our body. Blood pressure variability (BPV) is a newer parameter to assess the autonomic functions. Deranged cardiovascular autonomic functions are well-reported in diabetes mellitus. where chronic hyperglycemia is the basic pathology. But, role of acute hyperglycemia on cardiovascular autonomic functions in healthy subjects are less explored. Methods: Beat-to-beat blood pressure and electrocardiogram were recorded for the assessment of heart rate variability (HRV) and BPV in forty-two young, healthy subjects during fasting and hyperglycemic state. Correlations among analysed parameters of cardiovascular autonomic variabilities were explored. Results: We observed significant alteration of few of the systolic, mean, and diastolic BPV parameters during acute hyperglycemia when compared to the fasting state. However, no significant changes were observed in any of the HRV parameters. Also, we found novel significant correlations among many of the parameters HRV and BPV during fasting and hyperglycemic states. Conclusion: Present study concludes that the BPV is affected significantly during acute hyperglycemia in healthy late adolescents, however, the HRV does not show such changes. Also, many of the parameters of HRV and BPV show significant correlations.

Kiran Prakash
Government Medical College and Hospital
India

Navkiran Ranjan
Government Medical College and Hospital
India

Anita S Malhotra
Government Medical College and Hospital
India