Objectives Patients having Brugada Syndrome (BS), a rare inherited channelopathy, with an increased risk of arrhythmia, syncope and sudden cardiac death, may present seizures as uncommon clinical manifestations. The aim of this study was to report seizures phenotypes in BS patients who presented to our genetic counselling for SCN5a gene molecular exploration. Methods We selected through our genetic counselling reports of 2014, BS patients and collected informations about seizures. Results Five probands/families with BS were included. Only one patient presented a generalized convulsive crisis. He was a 24-year-old man from Sfax town, born from a consanguineous couple without any family history of sudden cardiac death. He was diagnosed at the age of 20 years when he visited the emergency due to nocturne tonic-clonic generalized seizures. The patient had no medical history. Physical examination, biological assessment, chest X-ray and electroencephalogram were normal. However, the electrocardiogram patterns were compatible with BS type 1. No SCN5a mutation was revealed. Conclusion BS patients may experience typical symptoms such as ventricular arrhythmias and syncope or may be asymptomatic. Symptoms that are more atypical may reveal the disease such as sudden nocturnal awakening, occasional nocturnal enuresis, nocturnal convulsions or nocturnal agonal breathing. This study highlights BS presented with epileptic seizures, that must be considered to prevent sudden cardiac death.

Nouha Bouayed Abdelmoula
Medical University of Sfax
Tunisia

Balkiss Abdelmoula
Medical University of Sfax
Tunisia