Background: In the treatment of infants with self-limited infantile epilepsy (SeLIE), anticonvulsant drugs may be used due to frequent seizures at the onset . Our aim is to evaluate the characteristics and treatment response in SeLIE patients, to promote early diagnosis. Material methods: The demographic and clinical of 72 patients with SeLIE who followed-up between April 2014 and March 2023 were assessed retrospectively. Results: Demographic and clinical characteristics of the patients are summarized in table-1. According to our results; 27 (37.6 %) patients had focal clonic seizures, 17 (23.6 %) patients had behavioral arrest, 16 (22.2 %) patients had generalized tonic clonic seizures, and 12 (16.6 %) patients had focal tonic seizures initiallyThe initial treatments and the rate of treatment responses are summarized in table-2. It was observed that levetiracetam was most commonly preferred as the first choice, but the highest seizure-free rate was achieved with treatment with carbamazepine. Among 16 (22.2%) patients who underwent molecular genetic analysis, disease-causing mutation in the PRRT-2 gene could be detected in one patient and the results of genetic analysis of the other patients are awaited. Conclusions: If afebrile focal tonic, clonic, behavioral arrest seizures occur in clusters in an infant with normal neuromotor development, SeLIE should be considered as a possible diagnosis and sodium channel blockers should be considered as the first drug.

Mehpare Sarı Yanartaş
Turkey

Furkan Donbaloğlu
Turkey

Şakir Genç
Turkey

Sait Açık
Turkey

Özlem Yayıcı Köken
Turkey

Şenay Haspolat
Turkey