Page 324 - ILAE_Lectures_2015

Table 1. Interactions between antiepileptic drugs (AEDs): Expected changes in plasma con

PRE-EX

CBZ CLB CZP ESL-a ESM FBM GBP LCM LTG LEV OXC PMP

CBZ AI CLB CZP ESL ESM FBM   LTG LEV H-OXC PM
CLB CBZ DMCLB NA  NA NA 
CZP CBZ-E — NA NA  NA NA   
ESL-a  — NA NA 
ESM NA — NA — NA NA NA   NA 
FBM  ? ? —  NCCP ?
GBP  NA  NA FBM  NA LTG 
LCM  NA NA NA 
LTG CBZ NA NA    NA NA  LEV NA ?
EV CBZ-E   NA —
OXC  CLB CZP NCCP ? ? NA NA LTG LEV ?
PMP DMCLB NA ? ? ? 
PB  NA ? ESM  — NA  LEV NA NA
PHT ESL ESM FBM LEV H-OXC ?
PGB  NA  NA NA NA — 
PRM ? ESM ? 
RTG   CZP ? NA NA NA  — NA  
RFN CBZ NA NA NA NA NA 
AED added STP CBZ  ? ESM ?  NA — PM
TGB CBZ NA NA NA  OXC** —
TPM CBZ ?? ESL NA ? NA  LTG 
VPA  ESM FBM 
VGB  CLB  NA NA  NA NA LTG 
ZNS CBZ NA ? ? NA
CLB CZP  LCM LTG H-OXC 
 DMCLB CZP
CBZ CLB NA  LCM LTG H-OXC PM
CBZ DMCLB
NA  NA  NA NA

? CZP NA ? LTG ??
 ??
CBZ-E NA NA NA NA LTG NA ?
CBZ
CBZ-E  NA NA NA LTG

CLB ? NA NA ? ??
DMCLB  NA
NA NA NA  NA NA

?? NA    PM

?   LTG 
NA NA
NA NA NA NA 

?? NA NA  ?

CBZ = carbamazepine; CBZ-E = carbamazepine-10,11-epoxide (active metabolite of CBZ); CLB = c
eslicarbazepine acetate; ESL = eslicarbazepine (active metabolite of ESL-a); ESM = ethosuximide; FB
LCM = lacosamide; LEV = levetiracetam; LTG = lamotrigine; OXC = oxcarbazepine; PB = phenobar
STP stiripentol; TGB = tiagabine; TPM = topiramate; VPA = valproic acid; VGB = vigabatrin; ZNS = z