Eeg In Neonatal Seizure: Prediction of Neurodevelopmental Outcome - A Study In A Tertiary Care Center In Bangladesh

ABSTRACT

Title: “EEG in Neonatal Seizure: Prediction of Neurodevelopmental Outcome – A Prospective Study in a Tertiary Care Hospital, Dhaka, Bangladesh Kazi Ashraful Islam, Naheed Nabi, Kanij Fatema, Shaheen Akhter

Background and Aims: Electroencephalogram (EEG) is one of the tools for assessing brain functional status. Different changes are found in EEG in neonatal seizures, among those findings background activity of EEG shows more impact on neurodevelopment. So we studied relation of EEG changes and neurodevelopmental outcome of infants with neonatal seizure. Method: This study seventy newborns with seizure were initially selected and finally, 66 babies were enrolled. EEG was done in all cases in the EEG lab of IPNA. A total of 50 infants completed their follow-up; developmental assessment was done using Rapid Neurodevelopmental Assessment tools. Result Overall, EEG was abnormal in 34 (68%) cases; background abnormality was present in 29 (58%) cases. Among abnormal EEG changes, focal discharges were 21 (61%) cases. At 3 months follow up 23(67%) of infants found one or more types of developmental impairment and epilepsy in 21 (61%) cases where initial EEG were abnormal. Most of the developmental impairment and epilepsy at follow-up were related with background abnormalities. Conclusion: Eighty percent of study subjects who had EEG abnormality showed any form of adverse neurodevelopmental outcome andepilepsy in one-third of cases.

Corresponding Author: Dr Kazi Ashraful Islam, Assistant Professor, Institute of Paediatric Neurodisorder & Autism, Bangabandhu Sheikh Mujib Medical University. Cell +880 1912178024, email ashrafrmc@gmail.com