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| neurolists:valproic_acid_and_lamotrigine [2024/03/10 04:59] – biju.hameed@gmail.com | neurolists:valproic_acid_and_lamotrigine [2024/03/10 05:03] (current) – biju.hameed@gmail.com | ||
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| ====== Using Valproic Acid and Lamotrigine ====== | ====== Using Valproic Acid and Lamotrigine ====== | ||
| * lamotrigine (LTG)in combination with valproic acid (VPA) may work synergistically to provide superior seizure control than each drug independently | * lamotrigine (LTG)in combination with valproic acid (VPA) may work synergistically to provide superior seizure control than each drug independently | ||
| + | * VPA inhibits LTG metabolism by UGT1A4 glucuronidation, | ||
| * Valproic acid (VPA) decreases lamotrigine (LTG) clearance by 30% at 125 mg/day and 50% at 250 mg and higher[(: | * Valproic acid (VPA) decreases lamotrigine (LTG) clearance by 30% at 125 mg/day and 50% at 250 mg and higher[(: | ||
| * maximal inhibition of LTG clearance by VPA occurs at doses of 500 mg/day | * maximal inhibition of LTG clearance by VPA occurs at doses of 500 mg/day | ||