neurolists:aed_drug_interactions

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neurolists:aed_drug_interactions [2022/05/01 00:39] – ↷ Page moved from aed_drug_interactions to neurolists:aed_drug_interactions administrator@icnapedia.orgneurolists:aed_drug_interactions [2024/02/20 21:18] (current) – administrator@icnapedia.org
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 ====== Antiseizure medications interactions ====== ====== Antiseizure medications interactions ======
 +<csv>
 +Expected changes in plasma concentrations when an AED is added to a pre-existing regimen,,,,,,,,,,,,,,,
 +AED added,PB,PHT,PRM,ETS,CBZ,VPA,OXC,LTG,GBP,TPM,TGB,LEV,ZNS,VGB,FBM
 +PB,-,PHT ↑↓,NCCP,ETS ↓↓,CBZ ↓↓,VPA ↓↓,H-OXC ↓,LTG ↓↓,↔,TPM ↓↓,TGB ↓↓,↔,ZNS ↓↓,↔,FBM ↓↓
 +PHT,PB ↑,-,PRM ↓ PB ↑,ETS ↓↓,CBZ ↓↓,VPA ↓↓,H-OXC ↓,LTG ↓↓,↔,TPM ↓↓,TGB ↓↓,↔,ZNS ↓↓,↔,FBM ↓↓
 +PRM,NCCP,PHT ↑↓,-,ETS ↓↓,CBZ ↓↓,VPA ↓↓,?,LTG ↓↓,↔,TPM ↓↓,TGB ↓↓,↔,ZNS ↓↓,↔,FBM ↓↓
 +ETS,↔,↔,NE,-,↔,VPA ↓,NE,NE,NE,NE,NE,NE,NE,NE,NE
 +CBZ,↔,PHT I↓,PRM ↓ PB ↑,ETS ↓↓,-,VPA ↓↓,H-OXC ↓,LTG ↓↓,↔,TPM ↓↓,TGB ↓↓,↔,ZNS ↓↓,NE,FBM ↓↓
 +VPA,PB ↑↑,PHT ↓*,PB ↑↑,ETS I↓,CBZ-E ↑,-,↔,LTG ↑↑,↔,TPM ↓,EE,↔,↔,NE,↔
 +OXC,PB ↑,PHT ↑,?,?,CBZ ↓,↔,-,LTG ↓,NE,?,?,NE,?,NE,?
 +LTG,↔,↔,NE,NE,↔,↔,NE,-,NE,NE,NE,↔,↔,NE,NE
 +GBP,↔,↔,NE,NE,↔,↔,NE,NE,-,NE,NE,↔,NE,NE,NE
 +TBP,↔,PHT ↑,↔,NE,↔,VPA ↓,?,?,NE,-,?,NE,?,NE,?
 +TGB,↔,↔,↔,NE,↔,↔,NE,NE,NE,NE,-,NE,NE,NE,NE
 +LEV,↔,↔,↔,NE,↔,↔,NE,↔,↔,NE,NE,-,NE,NE,NE
 +ZNS,↔,↔,NE,NE,CBA ↑↓,↔,?,↔,NE,NE,NE,NE,-,NE,?
 +VGB,PB ↓,PHT ↓,PRM ↓ PB ↓,NE,CBZ ↑,↔,NE,NE,NE,NE,NE,NE,NE,-,NE
 +FBM,PB ↑↑,PHT ↑↑,?,?,CBZ ↓ CBZ-E ↑,VPA ↑↑,↔,↔,NE,?,?,NE,?,↔,-
 +</csv>
  
-<html> 
-<style type="text/css"> 
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-</style> 
-<table border="1px" class="tg"> 
- <tbody> 
- <tr> 
- <th class="tg-yw4l" colspan="16">Expected changes in plasma concentrations when an AED is added to a pre-existing regimen</th> 
- </tr> 
- <tr> 
- <td class="tg-6k2t">AED added</td> 
- <td class="tg-6k2t">PB</td> 
- <td class="tg-6k2t">PHT</td> 
- <td class="tg-6k2t">PRM</td> 
- <td class="tg-6k2t">ETS</td> 
- <td class="tg-6k2t">CBZ</td> 
- <td class="tg-6k2t">VPA</td> 
- <td class="tg-6k2t">OXC</td> 
- <td class="tg-6k2t">LTG</td> 
- <td class="tg-6k2t">GBP</td> 
- <td class="tg-6k2t">TPM</td> 
- <td class="tg-6k2t">TGB</td> 
- <td class="tg-6k2t">LEV</td> 
- <td class="tg-6k2t">ZNS</td> 
- <td class="tg-6k2t">VGB</td> 
- <td class="tg-6k2t">FBM</td> 
- </tr> 
- <tr> 
- <td class="tg-yw4l">PB</td> 
- <td class="tg-yw4l">-</td> 
- <td class="tg-yw4l">PHT ↑↓</td> 
- <td class="tg-yw4l">NCCP</td> 
- <td class="tg-yw4l">ETS ↓↓</td> 
- <td class="tg-yw4l">CBZ ↓↓</td> 
- <td class="tg-yw4l">VPA ↓↓</td> 
- <td class="tg-yw4l">H-OXC ↓</td> 
- <td class="tg-yw4l">LTG ↓↓</td> 
- <td class="tg-yw4l">↔</td> 
- <td class="tg-yw4l">TPM ↓↓</td> 
- <td class="tg-yw4l">TGB ↓↓</td> 
- <td class="tg-yw4l">↔</td> 
- <td class="tg-yw4l">ZNS ↓↓</td> 
- <td class="tg-yw4l">↔</td> 
- <td class="tg-yw4l">FBM ↓↓</td> 
- </tr> 
- <tr> 
- <td class="tg-6k2t">PHT</td> 
- <td class="tg-6k2t">PB ↑</td> 
- <td class="tg-6k2t">-</td> 
- <td class="tg-6k2t">PRM ↓ PB ↑</td> 
- <td class="tg-6k2t">ETS ↓↓</td> 
- <td class="tg-6k2t">CBZ ↓↓</td> 
- <td class="tg-6k2t">VPA ↓↓</td> 
- <td class="tg-6k2t">H-OXC ↓</td> 
- <td class="tg-6k2t">LTG ↓↓</td> 
- <td class="tg-6k2t">↔</td> 
- <td class="tg-6k2t">TPM ↓↓</td> 
- <td class="tg-6k2t">TGB ↓↓</td> 
- <td class="tg-6k2t">↔</td> 
- <td class="tg-6k2t">ZNS ↓↓</td> 
- <td class="tg-6k2t">↔</td> 
- <td class="tg-6k2t">FBM ↓↓</td> 
- </tr> 
- <tr> 
- <td class="tg-yw4l">PRM</td> 
- <td class="tg-yw4l">NCCP</td> 
- <td class="tg-yw4l">PHT ↑↓</td> 
- <td class="tg-yw4l">-</td> 
- <td class="tg-yw4l">ETS ↓↓</td> 
- <td class="tg-yw4l">CBZ ↓↓</td> 
- <td class="tg-yw4l">VPA ↓↓</td> 
- <td class="tg-yw4l">?</td> 
- <td class="tg-yw4l">LTG ↓↓</td> 
- <td class="tg-yw4l">↔</td> 
- <td class="tg-yw4l">TPM ↓↓</td> 
- <td class="tg-yw4l">TGB ↓↓</td> 
- <td class="tg-yw4l">↔</td> 
- <td class="tg-yw4l">ZNS ↓↓</td> 
- <td class="tg-yw4l">↔</td> 
- <td class="tg-yw4l">FBM ↓↓</td> 
- </tr> 
- <tr> 
- <td class="tg-6k2t">ETS</td> 
- <td class="tg-6k2t">↔</td> 
- <td class="tg-6k2t">↔</td> 
- <td class="tg-6k2t">NE</td> 
- <td class="tg-6k2t">-</td> 
- <td class="tg-6k2t">↔</td> 
- <td class="tg-6k2t">VPA ↓</td> 
- <td class="tg-6k2t">NE</td> 
- <td class="tg-6k2t">NE</td> 
- <td class="tg-6k2t">NE</td> 
- <td class="tg-6k2t">NE</td> 
- <td class="tg-6k2t">NE</td> 
- <td class="tg-6k2t">NE</td> 
- <td class="tg-6k2t">NE</td> 
- <td class="tg-6k2t">NE</td> 
- <td class="tg-6k2t">NE</td> 
- </tr> 
- <tr> 
- <td class="tg-yw4l">CBZ</td> 
- <td class="tg-yw4l">↔</td> 
- <td class="tg-yw4l">PHT I↓</td> 
- <td class="tg-yw4l">PRM ↓ PB ↑</td> 
- <td class="tg-yw4l">ETS ↓↓</td> 
- <td class="tg-yw4l">-</td> 
- <td class="tg-yw4l">VPA ↓↓</td> 
- <td class="tg-yw4l">H-OXC ↓</td> 
- <td class="tg-yw4l">LTG ↓↓</td> 
- <td class="tg-yw4l">↔</td> 
- <td class="tg-yw4l">TPM ↓↓</td> 
- <td class="tg-yw4l">TGB ↓↓</td> 
- <td class="tg-yw4l">↔</td> 
- <td class="tg-yw4l">ZNS ↓↓</td> 
- <td class="tg-yw4l">NE</td> 
- <td class="tg-yw4l">FBM ↓↓</td> 
- </tr> 
- <tr> 
- <td class="tg-6k2t">VPA</td> 
- <td class="tg-6k2t">PB ↑↑</td> 
- <td class="tg-6k2t">PHT ↓*</td> 
- <td class="tg-6k2t">PB ↑↑</td> 
- <td class="tg-6k2t">ETS I↓</td> 
- <td class="tg-6k2t">CBZ-E ↑</td> 
- <td class="tg-6k2t">-</td> 
- <td class="tg-6k2t">↔</td> 
- <td class="tg-6k2t">LTG ↑↑</td> 
- <td class="tg-6k2t">↔</td> 
- <td class="tg-6k2t">TPM ↓</td> 
- <td class="tg-6k2t">EE</td> 
- <td class="tg-6k2t">↔</td> 
- <td class="tg-6k2t">↔</td> 
- <td class="tg-6k2t">NE</td> 
- <td class="tg-6k2t">↔</td> 
- </tr> 
- <tr> 
- <td class="tg-yw4l">OXC</td> 
- <td class="tg-yw4l">PB ↑</td> 
- <td class="tg-yw4l">PHT ↑</td> 
- <td class="tg-yw4l">?</td> 
- <td class="tg-yw4l">?</td> 
- <td class="tg-yw4l">CBZ ↓</td> 
- <td class="tg-yw4l">↔</td> 
- <td class="tg-yw4l">-</td> 
- <td class="tg-yw4l">LTG ↓</td> 
- <td class="tg-yw4l">NE</td> 
- <td class="tg-yw4l">?</td> 
- <td class="tg-yw4l">?</td> 
- <td class="tg-yw4l">NE</td> 
- <td class="tg-yw4l">?</td> 
- <td class="tg-yw4l">NE</td> 
- <td class="tg-yw4l">?</td> 
- </tr> 
- <tr> 
- <td class="tg-6k2t">LTG</td> 
- <td class="tg-6k2t">↔</td> 
- <td class="tg-6k2t">↔</td> 
- <td class="tg-6k2t">NE</td> 
- <td class="tg-6k2t">NE</td> 
- <td class="tg-6k2t">↔</td> 
- <td class="tg-6k2t">↔</td> 
- <td class="tg-6k2t">NE</td> 
- <td class="tg-6k2t">-</td> 
- <td class="tg-6k2t">NE</td> 
- <td class="tg-6k2t">NE</td> 
- <td class="tg-6k2t">NE</td> 
- <td class="tg-6k2t">↔</td> 
- <td class="tg-6k2t">↔</td> 
- <td class="tg-6k2t">NE</td> 
- <td class="tg-6k2t">NE</td> 
- </tr> 
- <tr> 
- <td class="tg-yw4l">GBP</td> 
- <td class="tg-yw4l">↔</td> 
- <td class="tg-yw4l">↔</td> 
- <td class="tg-yw4l">NE</td> 
- <td class="tg-yw4l">NE</td> 
- <td class="tg-yw4l">↔</td> 
- <td class="tg-yw4l">↔</td> 
- <td class="tg-yw4l">NE</td> 
- <td class="tg-yw4l">NE</td> 
- <td class="tg-yw4l">-</td> 
- <td class="tg-yw4l">NE</td> 
- <td class="tg-yw4l">NE</td> 
- <td class="tg-yw4l">↔</td> 
- <td class="tg-yw4l">NE</td> 
- <td class="tg-yw4l">NE</td> 
- <td class="tg-yw4l">NE</td> 
- </tr> 
- <tr> 
- <td class="tg-6k2t">TBP</td> 
- <td class="tg-6k2t">↔</td> 
- <td class="tg-6k2t">PHT ↑</td> 
- <td class="tg-6k2t">↔</td> 
- <td class="tg-6k2t">NE</td> 
- <td class="tg-6k2t">↔</td> 
- <td class="tg-6k2t">VPA ↓</td> 
- <td class="tg-6k2t">?</td> 
- <td class="tg-6k2t">?</td> 
- <td class="tg-6k2t">NE</td> 
- <td class="tg-6k2t">-</td> 
- <td class="tg-6k2t">?</td> 
- <td class="tg-6k2t">NE</td> 
- <td class="tg-6k2t">?</td> 
- <td class="tg-6k2t">NE</td> 
- <td class="tg-6k2t">?</td> 
- </tr> 
- <tr> 
- <td class="tg-yw4l">TGB</td> 
- <td class="tg-yw4l">↔</td> 
- <td class="tg-yw4l">↔</td> 
- <td class="tg-yw4l">↔</td> 
- <td class="tg-yw4l">NE</td> 
- <td class="tg-yw4l">↔</td> 
- <td class="tg-yw4l">↔</td> 
- <td class="tg-yw4l">NE</td> 
- <td class="tg-yw4l">NE</td> 
- <td class="tg-yw4l">NE</td> 
- <td class="tg-yw4l">NE</td> 
- <td class="tg-yw4l">-</td> 
- <td class="tg-yw4l">NE</td> 
- <td class="tg-yw4l">NE</td> 
- <td class="tg-yw4l">NE</td> 
- <td class="tg-yw4l">NE</td> 
- </tr> 
- <tr> 
- <td class="tg-6k2t">LEV</td> 
- <td class="tg-6k2t">↔</td> 
- <td class="tg-6k2t">↔</td> 
- <td class="tg-6k2t">↔</td> 
- <td class="tg-6k2t">NE</td> 
- <td class="tg-6k2t">↔</td> 
- <td class="tg-6k2t">↔</td> 
- <td class="tg-6k2t">NE</td> 
- <td class="tg-6k2t">↔</td> 
- <td class="tg-6k2t">↔</td> 
- <td class="tg-6k2t">NE</td> 
- <td class="tg-6k2t">NE</td> 
- <td class="tg-6k2t">-</td> 
- <td class="tg-6k2t">NE</td> 
- <td class="tg-6k2t">NE</td> 
- <td class="tg-6k2t">NE</td> 
- </tr> 
- <tr> 
- <td class="tg-yw4l">ZNS</td> 
- <td class="tg-yw4l">↔</td> 
- <td class="tg-yw4l">↔</td> 
- <td class="tg-yw4l">NE</td> 
- <td class="tg-yw4l">NE</td> 
- <td class="tg-yw4l">CBA ↑↓</td> 
- <td class="tg-yw4l">↔</td> 
- <td class="tg-yw4l">?</td> 
- <td class="tg-yw4l">↔</td> 
- <td class="tg-yw4l">NE</td> 
- <td class="tg-yw4l">NE</td> 
- <td class="tg-yw4l">NE</td> 
- <td class="tg-yw4l">NE</td> 
- <td class="tg-yw4l">-</td> 
- <td class="tg-yw4l">NE</td> 
- <td class="tg-yw4l">?</td> 
- </tr> 
- <tr> 
- <td class="tg-6k2t">VGB</td> 
- <td class="tg-6k2t">PB ↓</td> 
- <td class="tg-6k2t">PHT ↓</td> 
- <td class="tg-6k2t">PRM ↓ PB ↓</td> 
- <td class="tg-6k2t">NE</td> 
- <td class="tg-6k2t">CBZ ↑</td> 
- <td class="tg-6k2t">↔</td> 
- <td class="tg-6k2t">NE</td> 
- <td class="tg-6k2t">NE</td> 
- <td class="tg-6k2t">NE</td> 
- <td class="tg-6k2t">NE</td> 
- <td class="tg-6k2t">NE</td> 
- <td class="tg-6k2t">NE</td> 
- <td class="tg-6k2t">NE</td> 
- <td class="tg-6k2t">-</td> 
- <td class="tg-6k2t">NE</td> 
- </tr> 
- <tr> 
- <td class="tg-yw4l">FBM</td> 
- <td class="tg-yw4l">PB ↑↑</td> 
- <td class="tg-yw4l">PHT ↑↑</td> 
- <td class="tg-yw4l">?</td> 
- <td class="tg-yw4l">?</td> 
- <td class="tg-yw4l">CBZ ↓ CBZ-E ↑</td> 
- <td class="tg-yw4l">VPA ↑↑</td> 
- <td class="tg-yw4l">↔</td> 
- <td class="tg-yw4l">↔</td> 
- <td class="tg-yw4l">NE</td> 
- <td class="tg-yw4l">?</td> 
- <td class="tg-yw4l">?</td> 
- <td class="tg-yw4l">NE</td> 
- <td class="tg-yw4l">?</td> 
- <td class="tg-yw4l">↔</td> 
- <td class="tg-yw4l">-</td> 
- </tr> 
- </tbody> 
-</table></html> 
 PB = Phenobarbital; PHT = phenytoin; PRM = Primidone; ETS = Ethosuximide; CBZ = Carbamazepine; VPA = Valproic acid; OXC = Oxcarbazepine; LTG = Lamotrigine PB = Phenobarbital; PHT = phenytoin; PRM = Primidone; ETS = Ethosuximide; CBZ = Carbamazepine; VPA = Valproic acid; OXC = Oxcarbazepine; LTG = Lamotrigine
  
  • neurolists/aed_drug_interactions.txt
  • Last modified: 2024/02/20 21:18
  • by administrator@icnapedia.org