Lennox-Gastaut syndrome and Doose syndrome

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Feature	Lennox-Gastaut Syndrome	Doose Syndrome
Main seizures	Tonic; atonic and atypical absences	Myoclonic, atonic and myoclonic-atonic
Tonic seizures	Common and characteristic, diurnal and nocturnal	Probably exclusion criterion (nocturnal tonic seizures are accepted by some authors)
Tonic drop attacks	Common	Incompatible
Atypical absences	Common also occurring independently of other seizures	Uncommon, they usually accompany myoclonic or atonic episodes
Developmental abnormalities before onset of seizures	Common	Exceptional if any
Aetiology	Symptomatic or possibly symptomatic (idiopathic cases are accepted by some authorities)	Idiopathic1 (although symptomatic or possibly symptomatic cases are included in the ILAE classification of 198912)
Genetic predisposition	None	Common
Development from West syndrome	Common	Incompatible
EEG background	Abnormal by rule	Usually normal particularly at onset
EEG episodic fast activity and rapid spikes	Common and often characteristic	Exceptional and mainly in sleep
EEG slow generalised spike wave	Usually	Usually 2–3 Hz
Prognosis	Commonly bad	Commonly relatively good

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