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content:zonisamide [2020/02/13 15:52]
icna [Main ADRs]
content:zonisamide [2020/02/23 22:55] (current)
icna [Zonisamide]
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 ====== Zonisamide ====== ====== Zonisamide ======
- +Zonisamide is a synthetic 1,2-benzisoxazole derivative (1,2-benzisoxazole-3-methanesulfonamide). It is chemically classified as a sulfonamide with a structural similarity to serotoninIt was first introduced as an AED in Japan in 1989.
-Efficacydose and mean plasma levels were similar in multi-centre studies with Japanese and Caucasian subjects[(:cite:Wroe2009>Wroe SJ. Zonisamide. In: Shorvon SPerucca E, Engel JJr, eds. The treatment of epilepsy (3nd edition). Oxford: Willey-Blackwell, 2009:713-20.)] [(:cite:Chadwick2002>Chadwick DW, Marson AGZonisamide add-on for drug-resistant partial epilepsyCochrane Database Syst Rev 2002;2:CD001416.)]. +
 ===== Authorised indications ===== ===== Authorised indications =====
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 **Reference range:** 15–40 mg/l (45–180 μmol/l). **Reference range:** 15–40 mg/l (45–180 μmol/l).
 +see [[|Zonisamide in the British National Formulary]]
 ==== Main ADRs ==== ==== Main ADRs ====
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 ==== References ==== ==== References ====
-~~refnotes cite~~ +~~REFNOTES~~ 
-Wroe SJ. Zonisamide. In: Shorvon S, Perucca E, Engel JJr, eds. The treatment of epilepsy (3nd edition). Oxford: Willey-Blackwell, 2009:713-20. +~~AUTHORS~~ 
-Willmore LJ, Seino M. International experiences and perspectives: zonisamide. Seizure 2004;13 Suppl 1:S1–72. 620 A Clinical Guide to Epileptic Syndromes and their Treatment +{{tag>pharmacopoeia}}
-Chadwick DW, Marson AG. Zonisamide add-on for drug-resistant partial epilepsy. Cochrane Database Syst Rev 2002;(2):CD001416. +
-Baulac M. Introduction to zonisamide. Epilepsy Res 2006;68 Suppl 2:S3–9. +
-Tosches WA, Tisdell J. Long-term efficacy and safety of monotherapy and adjunctive therapy with zonisamide. Epilepsy Behav 2006;8:522–6. +
-Shinnar S, Pellock JM, Conry JA. Open-label, long-term safety study of zonisamide administered to children and adolescents with epilepsy. Eur J Paediatr Neurol 2009;13:3-9. +
-Arzimanoglou A, Rahbani A. Zonisamide for the treatment of epilepsy. Expert Rev Neurother 2006;6:1283–92. +
-Fukushima K, Seino M. A long-term follow-up of zonisamide monotherapy. Epilepsia 2006;47:1860–4. +
-Michael CT, Starr JL. Psychosis following initiation of zonisamide. Am J Psychiatry 2007;164:682. +
-Sills G, Brodie M. Pharmacokinetics and drug interactions with zonisamide. Epilepsia 2007;48:435–41. +
-Willmore LJ, Abelson MB, Ben-Menachem E, Pellock JM, Shields WD. Vigabatrin: 2008 update. Epilepsia 2009;50:163-173 +
-Mumford JP, Dam M. Meta-analysis of European placebo controlled studies of vigabatrin in drug resistant epilepsy. Br J Clin Pharmacol 1989;27:101S-107S.+
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