Differences

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--- content:vigabatrin [2020/02/23 18:14] – [Main disadvantages] icna
+++ content:vigabatrin [2020/02/23 18:15] – [Dosage and titration] icna
@@ Line 11: / Line 11: @@
 ===== Dosage and titration =====
-**Adults:** start treatment with 500 mg/day and titrate in increments of 500 mg/day every week. Typical adult maintenance dose is 1000–3000 mg/day given in two equally divided doses.
+**Adults:** start treatment with 500 mg/day and titrate in increments of 500 mg/day every week. Typical adult maintenance dose is 1000–3000 mg/day given in two equally divided doses.Because the excretion is mainly renal, the dose should be reduced in patients with renal insufficiency and creatinine clearance
-Because the excretion is mainly renal, the dose should be reduced in patients with renal insufficiency and creatinine clearance
 **Children with infantile spasms:** start treatment with 50 mg/kg/day and adjust according to the response over 7 days, up to a total of 150–200 mg/kg/day.
-Dosing: despite its short half-life (5–7 hours), vigabatrin may be given once or twice daily, because inhibition of GABA-T results in a relatively long duration of action, and GABA levels in the CSF can remain elevated for up to 120 hours after a single oral dose.
+**Dosing:** despite its short half-life (5–7 hours), vigabatrin may be given once or twice daily, because inhibition of GABA-T results in a relatively long duration of action, and GABA levels in the CSF can remain elevated for up to 120 hours after a single oral dose.
 **TDM:** unnecessary; useful only to check compliance.18,19
-Reference range: 6–278 μmol/l, which is irrelevant in clinical practice.
+**Reference range:** 6–278 μmol/l, which is irrelevant in clinical practice.
 ===== Adverse drug reactions =====