content:epileptic_encephalopathies

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Epileptic encephalopathies

Epileptic encephalopathies are a heterogenous group of conditions where the epileptic activity itself contributes to severe cognitive and behavioral impairments above and beyond what might be expected from the underlying pathology alone (e.g., cortical malformation), and that these can worsen over time”[1]. According to the ILAE commission (2017)[2] “in an epileptic encephalopathy, the abundant epileptiform activity interferes with development resulting in cognitive slowing and often regression, and sometimes is associated with psychiatric and behavioural consequences” and that the encephalopathic impact of the epileptiform activity could cause regression in patients with both normal development and pre-existing developmental delay, who then show developmental plateauing or regression.

The currently recognized epileptic encephalopathies are

One approach to epileptic encephalopathies is based on whether the presentation is with seizures as a prominent/unique symptom or where they are associated with movement disorders, dysmorphic features or multi-organ involvement.


1. a short:20196795
2. a short:28276062
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