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--- content:dravet_syndrome [2020/02/23 19:55] – [Epilepsy surgery] icna
+++ content:dravet_syndrome [2020/02/23 19:55] – [Epilepsy surgery] icna
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 Andrade et al (2010)[(:cite:19919661>{{pubmed>19919661}})] reported two adults aged 19&34 with Dravet syndrome who were treated with thalamic deep brain stimulation (DBS) , where the 19yr old showed marked improvement over a 10yr follow up, while the other did not.Small case series have also reported that palliative epilepsy surgery including Vagal Nerve Stimulation (VNS) and corpus callosotomy (CC) can be effective at reducing seizure frequency in Dravet syndrome[(:cite:27465677>{{pubmed>long:27465677}})].
-The presumed topography of the epileptogenic areas involves preferentially the mesial frontal lobe, the central area, sometimes the parietal and, even, the occipital lobes. Few interictal foci are localized in the temporal area. Surprisingly a hippocampal sclerosis has not been shown in the MRI of these patients who had prolonged and repeated severe FS[(:ref:todo)]
+The presumed topography of the epileptogenic areas involves preferentially the mesial frontal lobe, the central area, sometimes the parietal and, even, the occipital lobes. Few interictal foci are localized in the temporal area. Surprisingly a hippocampal sclerosis has not been shown in the MRI of these patients who had prolonged and repeated severe FS[(:ref:todo)].
 ===== Cannabidiol =====
   * Clinical trials show that cannabidiol reduces the number of convulsive and non-convulsive seizures when compared with usual care[(:cite:28813226>{{pubmed>28813226}})][(:cite:32040850>{{pubmed>32040850}})].