content:csf_immunoglobulins

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content:csf_immunoglobulins [2022/04/30 22:26] administrator@icnapedia.orgcontent:csf_immunoglobulins [2022/04/30 22:36] administrator@icnapedia.org
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 ====== Oligoclonal bands ====== ====== Oligoclonal bands ======
- +Oligoclonal bands (OCBs) are bands of immunoglobulins that are seen when a patient's blood serum, or cerebrospinal fluid (CSF) is analyzed. The presence of two or more bands of immunoglobulin on isoelectric focusing (IEF ) of
-The presence of two or more bands of immunoglobulin on isoelectric focusing (IEF ) of+
 CSF is referred to as 'oligoclonal bands' (OCBs). This CSF oligoclonal banding is only CSF is referred to as 'oligoclonal bands' (OCBs). This CSF oligoclonal banding is only
 indicative of local CNS IgG production when the banding pattern in the CSF is distinct indicative of local CNS IgG production when the banding pattern in the CSF is distinct
-from the pattern seen in the serum. For this reason a serum sample must be sent with a +from the pattern seen in the serum.
-CSF sample, as is done of course for the CSF:serum IgG index.+
  
 While OCBs are well known to assist in the diagnosis of multiple sclerosis it is While OCBs are well known to assist in the diagnosis of multiple sclerosis it is
-important to recognize that they are found in many other situations with infections +important to recognize that they are found in many other situations like 
-(subacute sclerosing panencephalitisrubella panencephalitisneurosyphilis, + 
-neuroborreliosisor autoimmunity (anti-NMDA receptor encephalitis).+infections 
 +  subacute sclerosing panencephalitis 
 +  * rubella panencephalitis 
 +  * neurosyphilis 
 +  neuroborreliosis 
 + 
 +or autoimmune conditions  
 +  * anti-NMDA receptor encephalitis) 
 +  * Guillain–Barré syndrome 
 +  * Neuromyelitic optica
  
 Although it has been suggested that in adults, where multiple sclerosis is a Although it has been suggested that in adults, where multiple sclerosis is a
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