Differences
This shows you the differences between two versions of the page.
Both sides previous revision Previous revision Next revision | Previous revision Next revisionBoth sides next revision | ||
content:csf_immunoglobulins [2022/04/30 22:26] – administrator@icnapedia.org | content:csf_immunoglobulins [2022/04/30 22:36] – administrator@icnapedia.org | ||
---|---|---|---|
Line 1: | Line 1: | ||
====== Oligoclonal bands ====== | ====== Oligoclonal bands ====== | ||
- | + | Oligoclonal bands (OCBs) are bands of immunoglobulins that are seen when a patient' | |
- | The presence of two or more bands of immunoglobulin on isoelectric focusing (IEF ) of | + | |
CSF is referred to as ' | CSF is referred to as ' | ||
indicative of local CNS IgG production when the banding pattern in the CSF is distinct | indicative of local CNS IgG production when the banding pattern in the CSF is distinct | ||
- | from the pattern seen in the serum. For this reason a serum sample must be sent with a | + | from the pattern seen in the serum. |
- | CSF sample, as is done of course for the CSF:serum IgG index. | + | |
While OCBs are well known to assist in the diagnosis of multiple sclerosis it is | While OCBs are well known to assist in the diagnosis of multiple sclerosis it is | ||
- | important to recognize that they are found in many other situations | + | important to recognize that they are found in many other situations |
- | (subacute sclerosing panencephalitis, rubella panencephalitis, neurosyphilis, | + | |
- | neuroborreliosis) or autoimmunity (anti-NMDA receptor encephalitis). | + | infections |
+ | | ||
+ | * rubella panencephalitis | ||
+ | * neurosyphilis | ||
+ | | ||
+ | |||
+ | or autoimmune conditions | ||
+ | * anti-NMDA receptor encephalitis) | ||
+ | * Guillain–Barré syndrome | ||
+ | * Neuromyelitic optica | ||
Although it has been suggested that in adults, where multiple sclerosis is a | Although it has been suggested that in adults, where multiple sclerosis is a |