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====== Childhood Epilepsy with centrotemporal spikes ====== | ====== Childhood Epilepsy with centrotemporal spikes ====== | ||
- | Self-Limited Epilepsy with Centrotemporal Spikes (SeLECTS) | + | see [[https:// |
- | epilepsy with centrotemporal spikes, benign epilepsy of childhood with centrotemporal | + | |
- | spikes or benign rolandic epilepsy) | + | |
- | + | ||
- | Childhood Epilepsy with centrotemporal spikes (CECTS), historically referred to as [[benign epilepsy with centrotemporal spikes]] (BECTS) or rolandic epilepsy, is the most common focal epilepsy syndrome of childhood, accounting for 15–20% of all childhood epilepsies. Childhood epilepsy with centrotemporal spikes, atypical childhood epilepsy with centrotemporal spikes, epileptic encephalopathy with continuous spike-and-wave during sleep, and Landau Kleffner syndrome are all conditions that share some EEG features. The focal seizures and cognitive impairment can be mild to severe. They are thought to comprise a phenotypic spectrum from rolandic epilepsy (also benign epilepsy with centrotemporal spikes, BECTS) to atypical benign partial epilepsy (ABPE), Landau-Kleffner syndrome (LKS) and epileptic encephalopathy with continuous spike and waves during slow-wave sleep (CSWS). | + | |
- | ==== Characteristic features ==== | + | |
- | * age-dependent epilepsy, with a typical onset at 5–8 years | + | |
- | * Most of the time it is a self-limiting epileptic syndrome, with seizure remission within adolescence | + | |
- | * Seizures predominantly occur during sleep, are usually stereotyped, | + | |
- | * seizures may evolve to a focal to bilateral tonic-clonic seizure | + | |
- | * Seizures are overall relatively infrequent, with 60–70% of patients experiencing two to ten seizures lifetime and 10–20% only one | + | |
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- | ==== EEG ==== | + | |
- | * normal background activity | + | |
- | * with stereotyped centrotemporal, | + | |
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- | Patients with CECTS may show " | + | |
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- | ==== Genetics ==== | + | |
- | * Centrotemporal spikes can be a trait that is passed down through siblings in a way that depends on their age and is autosomally dominant, even if they don't have seizures. | + | |
- | * Mutations in GRIN2A have been implicated in various types of Epilepsy-Aphasia-Spectrum (EAS) disordersS[(: | + | |
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- | ==== References ==== | + | |
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