content:cerebrospinal_fluid

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content:cerebrospinal_fluid [2020/02/17 12:39] – [References] icnacontent:cerebrospinal_fluid [2022/04/30 11:31] (current) administrator@icnapedia.org
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 In the neonatal period and later, a white blood cell (WBC) count up to 5/mm<sup>3</sup> is normal. The distribution is skewed to smaller numbers, such that the median neonatal WBC count is 1/mm<sup>3</sup>. Even 1 neutrophil/mm<sup>3</sup> should be considered as abnormal. The recognition of CSF malignant cells requires specialist expertise, but eosinophils are detectable with standard staining. In the neonatal period and later, a white blood cell (WBC) count up to 5/mm<sup>3</sup> is normal. The distribution is skewed to smaller numbers, such that the median neonatal WBC count is 1/mm<sup>3</sup>. Even 1 neutrophil/mm<sup>3</sup> should be considered as abnormal. The recognition of CSF malignant cells requires specialist expertise, but eosinophils are detectable with standard staining.
  
-Adjustment of CSF white blood cell counts in traumatic taps has been shown to be of little diagnostic utility[(:cite:18989240>{{pubmed>long:18989240}})].+Adjustment of CSF white blood cell counts in traumatic taps has been shown to be of little diagnostic utility[(:cite:18989240>{{pmid>long:18989240}})].
 ===== Protein ===== ===== Protein =====
 The protein in the CSF consists mostly of albumin, synthesized entirely extrathecally, and immunoglobulins - IgG, etc. - synthesized both extrathecally and intrathecally. The protein in the CSF consists mostly of albumin, synthesized entirely extrathecally, and immunoglobulins - IgG, etc. - synthesized both extrathecally and intrathecally.
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 Increase in CSF protein (albumin) occurs when there is disruption of the blood-brain barrier (and notably in polyneuropathy). Increase in CSF protein (albumin) occurs when there is disruption of the blood-brain barrier (and notably in polyneuropathy).
  
-Traumatic blood contamination may be expected to increase the CSF protein by around 1.1 mg/dL for every 1000 cell increase in CSF red blood cells per mm(3)[(:cite:21492866>{{pubmed>long:21492866}})] but, as with similar calculations on cell counts, caution is indicated.+Traumatic blood contamination may be expected to increase the CSF protein by around 1.1 mg/dL for every 1000 cell increase in CSF red blood cells per mm(3)[(:cite:21492866>{{pmid>long:21492866}})] but, as with similar calculations on cell counts, caution is indicated.
 ===== Albumin ===== ===== Albumin =====
 The concentration of Albumin in CSF is a reflection of the blood-CSF carrier since it comes entirely from outside the CSF. The concentration of Albumin in CSF is a reflection of the blood-CSF carrier since it comes entirely from outside the CSF.
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