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| content:cenobamate [2024/03/19 13:38] – [Mechanism of Action] biju.hameed@gmail.com | content:cenobamate [2024/03/19 15:48] (current) – [Mechanism of Action] biju.hameed@gmail.com |
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| * Positive allosteric modulator of GABA-A ion channel[(:cite:pmid32325146>{{pmid>long:32325146}})] | * Positive allosteric modulator of GABA-A ion channel[(:cite:pmid32325146>{{pmid>long:32325146}})] |
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| Makridis et al[(:cite:pmid35937072>{{pmid>long:35937072}})] reported their experience with CNB in 16 pediatric patients with Drug Resistant Epilepsy (DRE). CNB was initiated in pediatric patients at 12.5 mg once a day (0.22 mg/kg/d) and then titrated-up by 0.47 ± 0.27 mg/kg/d every 2 weeks.Treatment with CNB resulted in seizure-free or a significant seizure reduction of > 50% in more than two thirds of their patients. The rates of seizure freedom or strong reduction of seizure frequency were in line with data published for adults. No serious adverse events occurred in their cohort. | Makridis et al[(:cite:pmid35937072>{{pmid>long:35937072}})] reported their experience with CNB in 16 pediatric patients with Drug Resistant Epilepsy (DRE). CNB was initiated in pediatric patients at 12.5 mg once a day (0.22 mg/kg/d) and then titrated-up by 0.47 ± 0.27 mg/kg/d every 2 weeks.Treatment with CNB resulted in seizure-free or a significant seizure reduction of > 50% in more than two thirds of their patients. The rates of seizure freedom or strong reduction of seizure frequency were in line with data published for adults[(:ref:todo)]. No serious adverse events occurred in their cohort. |
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| Most frequent adverse effects in their cohort were somnolence/fatigue which occurred during up-titration, in line with other reports[(:cite:pmid32396252>{{pmid>long:32396252}})]. Less frequently vertigo, nausea, balance disorder, diplopia, increased impulsive/agitated behavior, increased appetite with weight gain and impaired sleep quality were reported. | Most frequent adverse effects in their cohort were somnolence/fatigue which occurred during up-titration, in line with other reports[(:cite:pmid32396252>{{pmid>long:32396252}})]. Less frequently vertigo, nausea, balance disorder, diplopia, increased impulsive/agitated behavior, increased appetite with weight gain and impaired sleep quality were reported. |
