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content:benign_non-familial_neonatal_epilepsy [2020/02/15 18:13] – [Prognosis] icna | content:benign_non-familial_neonatal_epilepsy [2022/04/30 11:31] (current) – administrator@icnapedia.org | ||
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Benign neonatal seizure (nonfamilial) is a benign syndrome characterized by clonic seizures that begin around the fifth day of life and may recur during the following 2 to 3 days. | Benign neonatal seizure (nonfamilial) is a benign syndrome characterized by clonic seizures that begin around the fifth day of life and may recur during the following 2 to 3 days. | ||
- | ===== History ===== | + | ===== History |
- | * Declan | + | * Dehan et al 1977[(: |
+ | * Prior & Macourt (1981)[(: | ||
* In 1989, the ILAE Commission on Classification and Terminology proposed the term " | * In 1989, the ILAE Commission on Classification and Terminology proposed the term " | ||
- | * In the updated ILAE 2017 classification it is categorized | + | * The [[content: |
===== Genetics ===== | ===== Genetics ===== | ||
* Claes et al 2004 reported three de novo mutations in KCNQ2 in 4 patients with benign neonatal seizures without a family history (Claes et al 2004). | * Claes et al 2004 reported three de novo mutations in KCNQ2 in 4 patients with benign neonatal seizures without a family history (Claes et al 2004). | ||
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===== Clinical features ===== | ===== Clinical features ===== | ||
* seizures are mainly clonic | * seizures are mainly clonic | ||
+ | * median duration is around 20hrs (status epilepticus)[(: | ||
* onset is around fifth day of life | * onset is around fifth day of life | ||
===== EEG ===== | ===== EEG ===== | ||
* ictal EEG usually shows localised spikes | * ictal EEG usually shows localised spikes | ||
- | * interictal EEG usually shows theta pointu alternant | + | * interictal EEG usually shows theta pointu alternant. It may also show focal or multifocal, non-specific abnormalities or a discontinuous pattern or it may be normal in ~10%. |
===== Pathophysiology ===== | ===== Pathophysiology ===== | ||
* probably environmental | * probably environmental | ||
+ | ===== Differential diagnosis ===== | ||
+ | * [[content: | ||
+ | * [[content: | ||
+ | * [[Benign infantile epilepsy]] | ||
===== Prognosis ===== | ===== Prognosis ===== | ||
- | * risk of subsequent seizures | + | |
+ | * normal neurodevelopmental outcome | ||
===== References ===== | ===== References ===== | ||
~~REFNOTES~~ | ~~REFNOTES~~ | ||
+ | {{tag> |